Department of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Department of Neurology, Saiseikai Matsuyama Hospital, Japan.
Intern Med. 2022 Mar 1;61(5):739-742. doi: 10.2169/internalmedicine.8747-21. Epub 2021 Dec 11.
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered worldwide. There have been reports of neurological adverse events following immunization (AEFIs). We herein report a case of refractory longitudinally extensive transverse myelitis in a 75-year-old Japanese man following the first dose of the BNT162b2 vaccine. The patient developed total sensory loss below the umbilicus and complete paralysis in both legs. Although he was treated with steroid therapy and plasma exchange, his recovery was limited, and severe sequelae remained. Further studies, including large epidemiological studies, are required to understand the association between SARS-CoV-2 vaccines and neurological AEFI.
全球已开发和接种了针对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的疫苗。有报道称，接种疫苗后会出现神经系统不良事件（AEFI）。本文报告了一名 75 岁日本男性在接种第一剂 BNT162b2 疫苗后出现难治性纵向广泛横贯性脊髓炎的病例。患者出现脐以下完全感觉丧失和双下肢完全瘫痪。尽管他接受了类固醇治疗和血浆置换，但他的恢复有限，仍存在严重后遗症。需要进一步研究，包括大型流行病学研究，以了解 SARS-CoV-2 疫苗与神经系统 AEFI 之间的关联。
