K Long Health Economics Consulting, LLC, St. Paul, Minnesota, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement. 2022 Mar;18(3):393-407. doi: 10.1002/alz.12400. Epub 2021 Sep 5.
Efforts to model the cost-effectiveness of managing/modifying cognitive impairment lack reliable, objective, baseline medical, and nursing-home (NH) costs.
A stratified-random sample of Olmsted County, MN, residents ages 70-89 years (N = 3545), well-characterized as cognitively unimpaired, mild cognitive impairment (MCI), or dementia, were followed forward ≤1 year in provider-linked billing data and the Centers for Medicare & Medicaid Services NH assessments. Direct medical/nursing home/medical + NH costs were estimated. Costs were stratified by vital status and NH-use intensity (NH days/follow-up days [0%, 1% to 24%, 25% to 99%, and 100%]). Between-category mean-annual cost differences were adjusted for patient characteristics and follow-up days.
Costs/follow-up day distributions differed significantly across cognitive categories. Mean costs/follow-up days were 2.5 to 18 times higher for decedents versus survivors. Among all persons with MCI, <9% with any NH use accounted for 18% of all total annual medical + NH costs. Adjusted-between-category comparisons revealed significantly higher medical and medical + NH costs for MCI versus cognitively unimpaired.
Cost-effectiveness for managing/modifying both MCI and dementia should consider end-of-life costs and NH-use intensity. Results can help inform cost-effectiveness models, predict future-care needs, and aid decision-making by individuals/providers/payers/policymakers.
缺乏可靠、客观的基线医疗和疗养院(NH)成本,使得管理/修改认知障碍的成本效益模型的努力受到阻碍。
明尼苏达州奥姆斯特德县的一个分层随机样本,年龄在 70-89 岁之间(N=3545),认知未受损、轻度认知障碍(MCI)或痴呆,在提供者相关的计费数据和医疗保险和医疗补助服务中心的疗养院评估中进行了≤1 年的前瞻性随访。直接医疗/疗养院/医疗+NH 成本被估计。根据生存状态和 NH 使用强度(NH 天数/随访天数[0%、1%至 24%、25%至 99%和 100%])对成本进行分层。对患者特征和随访天数进行调整后,计算出各分类之间的年度平均成本差异。
认知类别之间的成本/随访天数分布差异显著。死亡者的平均成本/随访天数是存活者的 2.5 至 18 倍。在所有患有 MCI 的人中,有任何 NH 使用的不到 9%,占所有年度医疗+NH 总费用的 18%。调整后的分类间比较显示,MCI 比认知未受损者的医疗和医疗+NH 成本显著更高。
管理/修改 MCI 和痴呆症的成本效益应考虑临终成本和 NH 使用强度。结果可以帮助为成本效益模型提供信息,预测未来的护理需求,并为个人/提供者/支付者/决策者提供决策辅助。