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Acta Biomater. 2020 Apr 1;106:54-69. doi: 10.1016/j.actbio.2020.02.003. Epub 2020 Feb 8.
3
Bioactive yet antimicrobial structurally stable collagen/chitosan/lysine functionalized hyaluronic acid - based injectable hydrogels for potential bone tissue engineering applications.具有生物活性且抗菌、结构稳定的胶原蛋白/壳聚糖/赖氨酸功能化透明质酸基可注射水凝胶，用于潜在的骨组织工程应用。
Int J Biol Macromol. 2020 Jul 15;155:938-950. doi: 10.1016/j.ijbiomac.2019.11.052. Epub 2019 Nov 9.
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聚-DL-乳酸/-磷酸三钙/羟基磷灰石/壳聚糖/神经生长因子缓释导管用于周围神经再生

PDLLA/-TCP/HA/CHS/NGF Sustained-release Conduits for Peripheral Nerve Regeneration.

作者信息

Yan Xiumei, Wang Jing, He Qundi, Xu Haixing, Tao Junyan, Koral Kelly, Li Kebi, Xu Jingyi, Wen Jing, Huang Zhijun, Xu Peihu

机构信息

Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070 China.

China Resources Sanjiu Medical & Pharmaceutical Co. Ltd., Shenzhen, 518029 China.

出版信息

J Wuhan Univ Technol Mater Sci Ed. 2021;36(4):600-606. doi: 10.1007/s11595-021-2450-6. Epub 2021 Aug 29.

DOI:10.1007/s11595-021-2450-6
PMID:34483596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8403253/
Abstract

Using nerve guide conduits (NGCs) to promote the regeneration of PNI is a feasible alternative to autograft. Compared with NGCs made of single material, composite NGCs have a greater development prospect. Our previous research has confirmed that poly(D, L-lactic acid)/-tricalcium phosphate/hyaluronic acid/chitosan/nerve growth factor (PDLLA/-TCP/HA/CHS/NGF) NGCs have excellent physical and chemical properties, which can slowly release NGF and support cell adhesion and proliferation. In this study, PDLLA/-TCP/HA/CHS/NGF NGCs were prepared and used to bridge a 10 mm sciatic nerve defect in 200-250 g Sprague-Dawley (SD) rat to verify the performance of the NGCs . Substantial improvements in nerve regeneration were observed after using the PDLLA/-TCP/HA/CHS/NGF NGCs based on gross post-operation observation, triceps wet weight analysis and nerve histological assessment. studies illustrate that the PDLLA/-TCP/HA/CHS/NGF sustained-release NGCs can effectively promote peripheral nerve regeneration, and the effect is similar to that of autograft.

摘要

使用神经引导导管（NGCs）促进周围神经损伤（PNI）的再生是自体移植的一种可行替代方案。与由单一材料制成的NGCs相比，复合NGCs具有更大的发展前景。我们之前的研究已经证实，聚（D，L-乳酸）/β-磷酸三钙/透明质酸/壳聚糖/神经生长因子（PDLLA/β-TCP/HA/CHS/NGF）NGCs具有优异的物理和化学性质，能够缓慢释放NGF并支持细胞黏附和增殖。在本研究中，制备了PDLLA/β-TCP/HA/CHS/NGF NGCs，并将其用于桥接200-250g 斯普拉格-道利（SD）大鼠10mm的坐骨神经缺损，以验证该NGCs的性能。基于术后大体观察、三头肌湿重分析和神经组织学评估，使用PDLLA/β-TCP/HA/CHS/NGF NGCs后观察到神经再生有显著改善。研究表明，PDLLA/β-TCP/HA/CHS/NGF缓释NGCs能够有效促进周围神经再生，其效果与自体移植相似。