Yao Xinlei, Xue Tong, Chen Bingqian, Zhou Xinyang, Ji Yanan, Gao Zihui, Liu Boya, Yang Jiawen, Shen Yuntian, Sun Hualin, Gu Xiaosong, Dai Bin
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, 226001, PR China.
Department of Paediatrics and Clinical Medicine, Medical School of Nantong University, Nantong University, Nantong, Jiangsu Province, 226001, PR China.
Bioact Mater. 2024 Dec 13;46:150-172. doi: 10.1016/j.bioactmat.2024.12.005. eCollection 2025 Apr.
Peripheral nerve injury is a common clinical disease. Effective post-injury nerve repair remains a challenge in neurosurgery, and clinical outcomes are often unsatisfactory, resulting in social and economic burden. Particularly, the repair of long-distance nerve defects remains a challenge. The existing nerve transplantation strategies show limitations, including donor site morbidity and immune rejection issues. The multiple studies have revealed the potential of tissue engineering strategies based on biomaterials in the repair of peripheral nerve injuries. We review the events of regeneration after peripheral nerve injury, evaluates the efficacy of existing nerve grafting strategies, and delves into the progress in the construction and application strategies of different nerve guidance conduits. A spotlight is cast on the materials, technologies, seed cells, and microenvironment within these conduits to facilitate optimal nerve regeneration. Further discussion was conducted on the approve of nerve guidance conduits and potential future research directions. This study anticipates and proposes potential avenues for future research, aiming to refine existing strategies and uncover innovative approaches in biomaterial-based nerve repair. This study endeavors to synthesize the collective insights from the fields of neuroscience, materials science, and regenerative medicine, offering a multifaceted perspective on the role of biomaterials in advancing the frontiers of peripheral nerve injury treatment.
周围神经损伤是一种常见的临床疾病。损伤后有效的神经修复仍是神经外科面临的一项挑战，临床疗效往往不尽人意，从而导致社会和经济负担。特别是，长距离神经缺损的修复仍然是一个挑战。现有的神经移植策略存在局限性，包括供体部位发病率和免疫排斥问题。多项研究揭示了基于生物材料的组织工程策略在周围神经损伤修复中的潜力。我们回顾了周围神经损伤后的再生过程，评估了现有神经移植策略的疗效，并深入探讨了不同神经导管构建及应用策略的进展。重点关注这些导管内的材料、技术、种子细胞和微环境，以促进最佳神经再生。还对神经导管的批准情况和潜在的未来研究方向进行了进一步讨论。本研究预期并提出了未来研究的潜在途径，旨在完善现有策略并发现基于生物材料的神经修复中的创新方法。本研究致力于综合神经科学、材料科学和再生医学领域的集体见解，从多方面阐述生物材料在推进周围神经损伤治疗前沿中的作用。
