Key Laboratory of Spectral Imaging Technology CAS, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Comput Math Methods Med. 2021 Aug 25;2021:3859386. doi: 10.1155/2021/3859386. eCollection 2021.
Because pulmonary vascular lesions are harmful to the human body and difficult to detect, computer-assisted diagnosis of pulmonary blood vessels has become the focus and difficulty of the current research. An algorithm of pulmonary vascular segment and centerline extraction which is consistent with the physician's diagnosis process is proposed for the first time. We construct the projection of maximum density, restore the vascular space information, and correct random walk algorithm to satisfy automatic and accurate segmentation of blood vessels. Construct a local 3D model to restrain Hessian matrix when extracting centerline. In order to assist the physician to make a correct diagnosis and verify the effectiveness of the algorithm, we proposed a visual expansion model. According to the 420 high-resolution CT data of lung blood vessels labeled by physicians, the accuracy of segmentation algorithm AOM reached 93%, and the processing speed was 0.05 s/frame, which achieved the clinical application standards.
由于肺血管病变对人体有害且难以检测,因此计算机辅助肺血管诊断已成为当前研究的重点和难点。本文首次提出了一种与医生诊断过程一致的肺血管段和中心线提取算法。我们构建了最大密度投影,恢复血管空间信息,并对随机游走算法进行修正,以满足血管的自动、准确分割。构建局部 3D 模型来约束提取中心线时的 Hessian 矩阵。为了协助医生进行正确诊断并验证算法的有效性,我们提出了一种可视化扩展模型。根据医生标注的 420 例肺部高分辨率 CT 血管数据,分割算法 AOM 的准确率达到 93%,处理速度为 0.05s/帧,达到了临床应用标准。