Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
School of Information Engineering, Zhengzhou University, Zhengzhou, China.
Front Public Health. 2021 Aug 17;9:687174. doi: 10.3389/fpubh.2021.687174. eCollection 2021.
Although high genetic risk and unhealthful lifestyles are associated with a high risk of hypertension, but the combined relationship between lifestyle score and genetic factors on blood pressure remains limited, especially in resource-constrained areas. To explore the separate and joint effects between genetic and lifestyle factors on blood pressure and hypertension in rural areas. In 4,592 adults from rural China with a 3-year of follow-up, a genetic risk score (GRS) was established using 13 single nucleotide polymorphisms (SNPs) and the lifestyle score was calculated including factors diet, body mass index (BMI), smoking status, drinking status, and physical activity. The associations of genetic and lifestyle factors with blood pressure and hypertension were determined with generalized linear and logistic regression models, respectively. The high-risk GRS was found to be associated with evaluated blood pressure and hypertension and the healthful lifestyle with diastolic blood pressure (DBP) level. Individuals with unhealthful lifestyles in the high GRS risk group had an odds ratio (OR) (95% CI) of 1.904 (1.006, 3.603) for hypertension than those with a healthful lifestyle in the low GRS risk group. Besides, the relative risk (RR), attributable risk (AR), and population attributable risk (PAR) for unhealthful lifestyle are 1.39, 5.87, 0.04%, respectively, and the prevented fraction for the population (PFP) for healthful lifestyle is 9.47%. These results propose a joint effect between genetic and lifestyle factors on blood pressure and hypertension. The findings provide support for adherence to a healthful lifestyle in hypertension precision prevention. The Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx?proj=11375.
虽然遗传风险高和不健康的生活方式与高血压风险高有关，但生活方式评分和遗传因素对血压的综合关系仍然有限，尤其是在资源有限的地区。本研究旨在探讨遗传和生活方式因素对农村地区血压和高血压的单独和联合作用。在随访 3 年的 4592 名中国农村成年人中，使用 13 个单核苷酸多态性（SNP）建立遗传风险评分（GRS），并计算包括饮食、体重指数（BMI）、吸烟状况、饮酒状况和身体活动在内的生活方式评分。使用广义线性和逻辑回归模型分别确定遗传和生活方式因素与血压和高血压的关系。高风险 GRS 与评估的血压和高血压相关，健康的生活方式与舒张压（DBP）水平相关。在高 GRS 风险组中，生活方式不健康的个体患高血压的比值比（OR）（95%CI）为 1.904（1.006，3.603），而低 GRS 风险组中生活方式健康的个体为 1.00。此外，不健康生活方式的相对风险（RR）、归因风险（AR）和人群归因风险（PAR）分别为 1.39、5.87 和 0.04%，健康生活方式的人群预防分数（PFP）为 9.47%。这些结果表明遗传和生活方式因素对血压和高血压有联合作用。研究结果为高血压精准预防中坚持健康生活方式提供了依据。河南农村队列研究已在中国临床试验注册中心（注册号：ChiCTR-OOC-15006699）注册。http://www.chictr.org.cn/showproj.aspx?proj=11375。
