利用弹性蛋白样多肽平台开发的新型蛋白质治疗药物。
Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform.
机构信息
Departments of Neurology, Cell and Molecular Biology, and Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi.
出版信息
Physiology (Bethesda). 2021 Nov 1;36(6):367-381. doi: 10.1152/physiol.00026.2021. Epub 2021 Sep 6.
Abstract
Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.
摘要
弹性蛋白样多肽（ELPs）是一种经过生物工程改造的蛋白质，具有独特的物理特性，即热触发的相反相转变，可用于药物输送。ELP 融合蛋白可用作可溶性生物制剂、热靶向药物载体、自组装纳米颗粒和缓控释药物库。由于其独特的物理特性和对几乎任何类型治疗药物的输送的多功能性，基于 ELP 的药物输送系统代表了生物制剂开发的一个有前途的平台。
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