Zhuang Xuan-Miao, Kuo Li-Wei, Lin Shih-Yen, Yang Jir-Jei, Tu Min-Chien, Hsu Yen-Hsuan
Department of Psychology, National Chung Cheng University, Chiayi, Taiwan.
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan.
Front Aging Neurosci. 2021 Aug 20;13:686040. doi: 10.3389/fnagi.2021.686040. eCollection 2021.
Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patients with early stage SIVD as compared to those with Alzheimer's disease (AD) and to older adults with normal cognition, and to explore the neural correlates of PM deficits. Patients with very-mild to mild dementia due to SIVD or AD and normal controls (NC) aged above 60 years were recruited. Seventy-three participants (20 SIVD, 22 AD, and 31 NC) underwent structural magnetic resonance imaging (MRI), cognitive screening tests, and a computerized PM test. Sixty-five of these participants (19 SIVD, 20 AD, and 26 NC) also received resting-state functional MRI. The group with SIVD had significantly fewer PM hits than the control group on both time-based and non-focal event-based PM tasks. Among patients in the very early stage, only those with SIVD but not AD performed significantly worse than the controls. Correlational analyses showed that non-focal event-based PM in SIVD was positively correlated with regional homogeneity in bilateral superior and middle frontal gyri, while time-based PM was not significantly associated with regional homogeneity in any of the regions of interest within the dorsal frontoparietal regions. The findings of this study highlight the vulnerability of non-focal event-based PM to the disruption of regional functional connectivity in bilateral superior and middle frontal gyri in patients with SIVD.
皮质下缺血性血管疾病（SIVD）患者通常存在明显的额叶功能障碍。然而，SIVD如何影响前瞻性记忆（PM）仍不清楚，前瞻性记忆强烈依赖于额顶叶网络。本研究旨在调查早期SIVD患者与阿尔茨海默病（AD）患者以及认知正常的老年人相比的PM表现，并探索PM缺陷的神经相关性。招募了因SIVD或AD导致极轻度至轻度痴呆的患者以及60岁以上的正常对照（NC）。73名参与者（20名SIVD患者、22名AD患者和31名NC）接受了结构磁共振成像（MRI）、认知筛查测试和计算机化的PM测试。其中65名参与者（19名SIVD患者、20名AD患者和26名NC）还接受了静息态功能MRI检查。在基于时间和非焦点事件的PM任务中，SIVD组的PM命中次数均显著少于对照组。在极早期患者中，只有SIVD患者而非AD患者的表现明显比对照组差。相关性分析表明，SIVD患者基于非焦点事件的PM与双侧额上回和额中回的区域同质性呈正相关，而基于时间的PM与背侧额顶叶区域内任何感兴趣区域的区域同质性均无显著关联。本研究结果突出了SIVD患者基于非焦点事件的PM对双侧额上回和额中回区域功能连接中断的易损性。
