Yue Jinhuan, Wang Peng, Guo Xiang-Fa, Wei Zeyi, He Kaiting, Li Nuo, Li Xiaoling, Zhang Qinhong, Zhou Xiaoqing
Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China.
Vitality University, Hayward, CA United States.
Front Aging Neurosci. 2025 Jul 4;17:1547965. doi: 10.3389/fnagi.2025.1547965. eCollection 2025.
Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies.
血管性痴呆（VD）是一种由各种脑血管疾病引起的严重认知障碍综合征，是老年痴呆症的主要病因之一。近年来，其发病率一直在稳步上升。鉴于缺乏针对VD的特异性治疗方法，早期检测、诊断和干预至关重要。本综述在VD背景下研究了关于静息态功能磁共振成像（rs-fMRI）的现有文献，重点关注低频波动幅度（ALFF）、局部一致性（ReHo）和功能连接（FC）等关键指标。通过分析通过rs-fMRI观察到的VD患者脑功能活动的变化，本研究旨在提供重要的影像学见解，以支持和加强临床治疗策略。
