• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中国湖北 2018-2019 年人类腺病毒 7 型感染：流行特征及所检测病毒的遗传特征。

Human Adenovirus Type 7 Infections in Hubei, China During 2018-2019: Epidemic Features and Genetic Characterization of the Detected Viruses.

机构信息

Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.

出版信息

Front Cell Infect Microbiol. 2021 Aug 19;11:684606. doi: 10.3389/fcimb.2021.684606. eCollection 2021.

DOI:10.3389/fcimb.2021.684606
PMID:34490137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8417316/
Abstract

Human adenoviruses (HAdVs) type 7 can cause severe respiratory disease. During the period between December 2018 and August 2019, HAdV-7 infection was identified in 129 patients in Wuhan Children's Hospital, Hubei Province, China. Samples were collected from hospitalized children and metagenomic sequencing was applied to detect the HAdV infections. Hemophagocytic lymphohistiocystosis (HLH) related to HAdV infections was observed in some patients clinically and patients were divided into two groups based on this to test the differences among clinical indicators. Genome variation, restriction endonuclease analysis (REA), and phylogenetic analyses were carried out to show the genome characterization of HAdV-7 in this study. It was found that many indicators, such as all blood routine indicators, in patients of the HLH group showed significant levels. In this study, REA revealed that HAdV-7 might belong to genome 7d and genome variation analysis displayed the stable genome of HAdV. HAdV-7 is an ongoing threat to the public, and global surveillance should be established.

摘要

人类腺病毒（HAdV）7 型可引起严重的呼吸道疾病。2018 年 12 月至 2019 年 8 月期间，中国湖北省武汉儿童医院确诊了 129 例 HAdV-7 感染患者。从住院患儿中采集样本，并应用宏基因组测序来检测 HAdV 感染。临床上观察到一些患者与 HAdV 感染相关的噬血细胞性淋巴组织细胞增生症（HLH），并根据此将患者分为两组，以检测临床指标的差异。本研究对 HAdV-7 的基因组变异、限制性内切酶分析（REA）和系统进化分析进行了研究，以展示 HAdV-7 的基因组特征。结果发现，HLH 组患者的许多指标，如所有血常规指标，均显示出显著水平。本研究中，REA 表明 HAdV-7 可能属于基因组 7d，基因组变异分析显示 HAdV 的基因组稳定。HAdV-7 是对公众的持续威胁，应建立全球监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/f751a6cfd3c6/fcimb-11-684606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/d529b33919bf/fcimb-11-684606-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/9701b654a595/fcimb-11-684606-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/1875b7df5d3d/fcimb-11-684606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/9e414acd1018/fcimb-11-684606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/f751a6cfd3c6/fcimb-11-684606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/d529b33919bf/fcimb-11-684606-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/9701b654a595/fcimb-11-684606-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/1875b7df5d3d/fcimb-11-684606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/9e414acd1018/fcimb-11-684606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d4/8417316/f751a6cfd3c6/fcimb-11-684606-g005.jpg

相似文献

1
Human Adenovirus Type 7 Infections in Hubei, China During 2018-2019: Epidemic Features and Genetic Characterization of the Detected Viruses.中国湖北 2018-2019 年人类腺病毒 7 型感染：流行特征及所检测病毒的遗传特征。
Front Cell Infect Microbiol. 2021 Aug 19;11:684606. doi: 10.3389/fcimb.2021.684606. eCollection 2021.
2
Re-emergent human adenovirus genome type 7d caused an acute respiratory disease outbreak in Southern China after a twenty-one year absence.在消失21年后，重新出现的人类腺病毒7d型在中国南方引发了一场急性呼吸道疾病疫情。
Sci Rep. 2014 Dec 8;4:7365. doi: 10.1038/srep07365.
3
Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019.2017 年至 2019 年期间，在中国广州一家三级医院住院的呼吸道感染患者中人类腺病毒的分子分型。
BMC Infect Dis. 2021 Aug 3;21(1):748. doi: 10.1186/s12879-021-06412-0.
4
Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013.2012 - 2013年中国南方住院儿童急性呼吸道感染相关人腺病毒的分子鉴定及流行病学特征
PLoS One. 2016 May 12;11(5):e0155412. doi: 10.1371/journal.pone.0155412. eCollection 2016.
5
An outbreak of acute respiratory infection at a training base in Beijing, China due to human adenovirus type B55.中国北京某培训基地发生的由人腺病毒 B55 型引起的急性呼吸道感染暴发。
BMC Infect Dis. 2020 Jul 23;20(1):537. doi: 10.1186/s12879-020-05258-2.
6
Human adenovirus among hospitalized children with respiratory tract infections in Beijing, China, 2017-2018.中国北京 2017-2018 年住院呼吸道感染患儿中的人腺病毒。
Virol J. 2019 Jun 13;16(1):78. doi: 10.1186/s12985-019-1185-x.
7
Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008-2013.2008-2013 年中国北京儿童急性下呼吸道感染中人腺病毒 55 型和 7 型感染的流行病学和临床特征的病例对照研究。
BMC Infect Dis. 2018 Dec 7;18(1):634. doi: 10.1186/s12879-018-3520-z.
8
Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012.2007年至2012年中国北京急性下呼吸道感染儿童的腺病毒感染情况
BMC Infect Dis. 2015 Oct 1;15:408. doi: 10.1186/s12879-015-1126-2.
9
Human adenoviruses in paediatric patients with respiratory tract infections in Beijing, China.中国北京呼吸道感染患儿中的人腺病毒。
Virol J. 2021 Sep 23;18(1):191. doi: 10.1186/s12985-021-01661-6.
10
Molecular and clinical characterization of human adenovirus associated with acute respiratory tract infection in hospitalized children.住院儿童急性呼吸道感染相关人腺病毒的分子与临床特征
J Clin Virol. 2020 Feb;123:104254. doi: 10.1016/j.jcv.2019.104254. Epub 2019 Dec 25.

引用本文的文献

1
GSK3A promotes human adenovirus replication and phosphorylates viral L4-22K protein.糖原合成酶激酶3A促进人腺病毒复制并使病毒L4-22K蛋白磷酸化。
Life Sci Alliance. 2025 Jun 19;8(9). doi: 10.26508/lsa.202503320. Print 2025 Sep.
2
Human adenovirus type 7 subunit vaccine induces dendritic cell maturation through the TLR4/NF-κB pathway is highly immunogenic.人腺病毒 7 型亚单位疫苗通过 TLR4/NF-κB 通路诱导树突状细胞成熟，具有高度的免疫原性。
Front Cell Infect Microbiol. 2023 Apr 12;13:1117230. doi: 10.3389/fcimb.2023.1117230. eCollection 2023.
3
Genetic characterization of human adenoviruses in patients using metagenomic next-generation sequencing in Hubei, China, from 2018 to 2019.

本文引用的文献

1
Human Adenovirus 7-Associated Hemophagocytic Lymphohistiocytosis-like Illness: Clinical and Virological Characteristics in a Cluster of Five Pediatric Cases.人腺病毒 7 相关噬血细胞性淋巴组织细胞增生症样疾病：5 例儿科聚集性病例的临床和病毒学特征。
Clin Infect Dis. 2021 Oct 5;73(7):e1532-e1538. doi: 10.1093/cid/ciaa1277.
2
[Clinical features of children with severe adenovirus pneumonia and hemophagocytic syndrome: an analysis of 30 cases].[重症腺病毒肺炎合并噬血细胞综合征患儿的临床特征：30例分析]
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Jul;22(7):744-748. doi: 10.7499/j.issn.1008-8830.2003080.
3
Genetic variability of human adenovirus type 7 circulating in mainland China.
2018年至2019年在中国湖北，运用宏基因组下一代测序技术对患者体内人腺病毒进行基因特征分析。
Front Microbiol. 2023 Mar 16;14:1153728. doi: 10.3389/fmicb.2023.1153728. eCollection 2023.
4
Comparisons of lymphocytes profiles and inflammatory cytokines levels in blood of patients with differed severity of infection by human adenovirus type 7.比较不同严重程度人腺病毒 7 型感染患者血液中淋巴细胞谱和炎症细胞因子水平。
BMC Infect Dis. 2023 Mar 22;23(1):174. doi: 10.1186/s12879-023-08132-z.
中国内地流行的人类腺病毒 7 型的遗传变异。
PLoS One. 2020 Apr 30;15(4):e0232092. doi: 10.1371/journal.pone.0232092. eCollection 2020.
4
Pediatric hemophagocytic lymphohistiocytosis.儿童噬血细胞性淋巴组织细胞增生症。
Blood. 2020 Apr 16;135(16):1332-1343. doi: 10.1182/blood.2019000936.
5
SciPy 1.0: fundamental algorithms for scientific computing in Python.SciPy 1.0：Python 中的科学计算基础算法。
Nat Methods. 2020 Mar;17(3):261-272. doi: 10.1038/s41592-019-0686-2. Epub 2020 Feb 3.
6
Human adenovirus among hospitalized children with respiratory tract infections in Beijing, China, 2017-2018.中国北京 2017-2018 年住院呼吸道感染患儿中的人腺病毒。
Virol J. 2019 Jun 13;16(1):78. doi: 10.1186/s12985-019-1185-x.
7
Human adenovirus type 7 infection causes a more severe disease than type 3.人腺病毒 7 型感染比 3 型引起更严重的疾病。
BMC Infect Dis. 2019 Jan 9;19(1):36. doi: 10.1186/s12879-018-3651-2.
8
Neonatal Adenovirus Infection Complicated by Hemophagocytic Lymphohistiocytosis Syndrome.新生儿腺病毒感染合并噬血细胞性淋巴组织细胞增生症。
Pediatrics. 2018 Apr;141(Suppl 5):S475-S480. doi: 10.1542/peds.2017-2061.
9
Viral and Bacterial Etiologies of Acute Respiratory Infections Among Children Under 5 Years in Senegal.塞内加尔5岁以下儿童急性呼吸道感染的病毒和细菌病因
Microbiol Insights. 2018 Feb 13;11:1178636118758651. doi: 10.1177/1178636118758651. eCollection 2018.
10
MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.MAFFT 在线服务：多序列比对、交互式序列选择和可视化。
Brief Bioinform. 2019 Jul 19;20(4):1160-1166. doi: 10.1093/bib/bbx108.