Yuan Chao, Guo Yuhua, Wang Ke, Wang Zhunian, Li Longfei, Zhu Huajie, Li Gang
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences CATAS, Haikou, China.
Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences CATAS, Haikou, China.
Front Chem. 2021 Aug 24;9:734822. doi: 10.3389/fchem.2021.734822. eCollection 2021.
Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid () and austdiol (), and their novel heterotrimer, muyophilone A (), were isolated and identified from an endophytic fungus, 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of , two compound -derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound . Compound represents the first example of azaphilone heterotrimers.
从内生真菌0307-2中分离并鉴定出两种已知的氮杂环庚三烯酮衍生物，4,6-二甲基弯孢霉菌酸（）和澳洲二醇（），以及它们的新型异三聚体，嗜木霉素A（）。通过包括高分辨质谱（HRMS）、核磁共振光谱（NMR）、电子圆二色光谱（ECD）和振动圆二色光谱（VCD）等广泛的光谱分析方法以及单晶X射线衍射确定了它们的结构和立体化学。在的结构中，两个源自化合物的氮杂环庚三烯酮单元通过一个前所未有的五元碳桥相连，该桥被认为源自化合物。化合物代表了氮杂环庚三烯酮异三聚体的首个实例。
