来自超深渊海沟真菌YP-106的促血管生成新型氯杂蒽酮衍生物
Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus YP-106.
作者信息
Fan Yaqin, Jiang Chunjiao, Zhang Yan, Ma Zhiheng, Li Peihai, Guo Lizhong, Feng Ting, Zhou Liman, Xu Lili
机构信息
Shandong Provincial Key Laboratory of Applied Mycology, School of Life Sciences, Qingdao Agricultural University, Qingdao, China.
Shandong Provincial Engineering Laboratory for Biological Testing Technology, Key Laboratory for Biosensor of Shandong Province, Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
出版信息
Front Microbiol. 2022 Jul 22;13:943452. doi: 10.3389/fmicb.2022.943452. eCollection 2022.
Five new chloro-azaphilones, chaetofanixins A-E (1-5), and five known analogs (6-10) were isolated and identified from the hadal trench-derived fungus YP-106. The structure of chaetofanixin E (5) is unique and interesting, bearing a highly rigid 6/6/5/3/5 penta-cyclic ring system, which is first encountered in natural products. The structures of these compounds, including absolute configurations, were determined based on the spectroscopic analysis, electronic circular dichroism (ECD) calculations, and analysis of biogenetic origins. Compounds 1-7 significantly promoted angiogenesis in a dose-dependent manner, and thus, these compounds might be used as promising molecules for the development of natural cardiovascular disease agents.
从超深渊海沟来源的真菌YP-106中分离并鉴定出5个新的氯杂蒽酮类化合物，即chaetofanixins A-E（1-5）以及5个已知类似物（6-10）。Chaetofanixin E（5）的结构独特且有趣，具有高度刚性的6/6/5/3/5五环体系，这是在天然产物中首次发现。这些化合物的结构，包括绝对构型，是通过光谱分析、电子圆二色光谱（ECD）计算以及生源起源分析确定的。化合物1-7以剂量依赖的方式显著促进血管生成，因此，这些化合物可能是开发天然心血管疾病药物的有前景的分子。
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