Yu Dongming, Xia Yaoyao, Ge Liangpeng, Tan Bie, Chen Shuai
Guangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Chongqing Academy of Animal Sciences, Chongqing, China.
Front Nutr. 2021 Aug 19;8:713256. doi: 10.3389/fnut.2021.713256. eCollection 2021.
Post-weaning diarrhea of piglets is associated with gut microbiota dysbiosis and intestinal pathogen infection. Recent studies have shown that () could help suppress pathogen infection. This study aimed to investigate the effects of on various factors related to growth and immunity in weaning piglets. The results showed that improved the growth performance, regulated the amino acid profile (for example, increasing serum tryptophan and ileal mucosal cystine) and the intestinal GABAergic system (including inhibiting ileal gene expression of SLC6A13, GABAAρ1, π, θ, and γ1, and promoting ileal GABAAα5 expression). also modulated intestinal immunity by promoting jejunal interleukin 17, 18, 22, ileal toll-like receptor 2, 5, 6, and myeloid differentiation primary response protein 88 gene expression while inhibiting jejunal interferon-γ and ileal interleukin 22 expressions. highly affected the intestinal microbiota by improving the beta diversity of gut microbiota and the relative abundance of and . In conclusion, improved the growth performance and regulated amino acid profiles, intestinal immunity and microbiota in weaning piglets.
仔猪断奶后腹泻与肠道微生物群失调和肠道病原体感染有关。最近的研究表明，（）有助于抑制病原体感染。本研究旨在探讨（）对断奶仔猪生长和免疫相关各种因素的影响。结果表明，（）改善了生长性能，调节了氨基酸谱（例如，增加血清色氨酸和回肠黏膜胱氨酸）和肠道GABA能系统（包括抑制回肠SLC6A13、GABAAρ1、π、θ和γ1的基因表达，并促进回肠GABAAα5表达）。（）还通过促进空肠白细胞介素17、18、22、回肠Toll样受体2、5、6和髓样分化初级反应蛋白88基因表达，同时抑制空肠干扰素-γ和回肠白细胞介素22表达来调节肠道免疫。（）通过改善肠道微生物群的β多样性以及（）和（）的相对丰度，对肠道微生物群产生了高度影响。总之，（）改善了断奶仔猪的生长性能，调节了氨基酸谱、肠道免疫和微生物群。
