J Drugs Dermatol. 2021 Sep 1;20(9):996-1003. doi: 10.36849/jdd.5818.
Skin aging is a multifactorial process induced by intrinsic factors such as metabolic processes and senescence as well as environmental factors, including smoking, air pollution, and solar radiation. UV-induced production of reactive oxygen species induces skin photoaging. Antioxidants, including vitamin C and E and green tea polyphenols represent a promising strategy for the aesthetic improvement of clinical features associated with aging.
To assess the safety, tolerability, and efficacy of a novel vitamin C and E and green tea polyphenols (CE-GTP) combination serum on photoaged facial skin.
31 healthy females aged 43 to 65 years (mean age, 57.9) participated in this single-center, 12-week clinical trial. Subjects applied CE-GTP serum twice daily for the duration of the study. Clinical grading of efficacy parameters, safety and tolerability evaluations, ultrasound measurements, and self-assessment questionnaires were conducted at several study milestones.
Statistically significant improvements were observed in all clinically graded efficacy parameters. Highlights include reduction in fine lines around the eye area and facial wrinkles and enhanced skin smoothness and radiance. Ultrasound measurements showed a statistically significant increase in skin density at week 12 compared with baseline, indicating thickening of the epidermal and dermal tissue, associated with youthful, healthier skin. Subjects self-reported numerous improvements, including reduction of fine lines and wrinkles, improved skin tone and texture, diminished look of dark spots, and improved skin elasticity.
Novel CE-GTP serum is safe and effective, as shown by statistically significant improvements in multiple aesthetically important objective, subjective, and patient reported outcomes. J Drugs Dermatol. 2021;20(9):996-1003. doi:10.36849/JDD.5818.
皮肤老化是一个由内在因素（如新陈代谢和衰老）以及环境因素（包括吸烟、空气污染和太阳辐射）引起的多因素过程。UV 诱导的活性氧产生诱导皮肤光老化。抗氧化剂，包括维生素 C 和 E 以及绿茶多酚，是改善与衰老相关的临床特征的有前途的策略。
评估新型维生素 C 和 E 与绿茶多酚（CE-GTP）组合血清对面部光老化皮肤的安全性、耐受性和疗效。
31 名年龄在 43 至 65 岁（平均年龄 57.9 岁）的健康女性参加了这项为期 12 周的单中心临床试验。研究期间，受试者每天两次涂抹 CE-GTP 血清。在多个研究里程碑处进行了疗效参数的临床分级、安全性和耐受性评估、超声测量和自我评估问卷。
所有临床分级的疗效参数均观察到统计学显著改善。亮点包括减少眼周和面部皱纹的细纹，以及增强皮肤的光滑度和光泽度。超声测量显示，与基线相比，第 12 周皮肤密度有统计学显著增加，表明表皮和真皮组织增厚，与年轻、更健康的皮肤相关。受试者自我报告了许多改善，包括减少细纹和皱纹、改善肤色和质地、减少黑斑的外观以及改善皮肤弹性。
新型 CE-GTP 血清是安全有效的，多项美观重要的客观、主观和患者报告的结果均显示出统计学显著改善。J 皮肤病药物学杂志。2021；20(9)：996-1003。doi：10.36849/JDD.5818.
