Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Department of Gastroenterology & Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Sci Rep. 2021 Sep 7;11(1):17762. doi: 10.1038/s41598-021-97209-3.
To establish age- and sex-specific distribution of the infrarenal abdominal aortic diameters (IAD) among non-aneurysmal elderly population and to investigate the associations between traditional cardiovascular risk factors and IAD in men and women. We included 4032 participants (mean age 67.2 years; 60.4% women) from the population-based Rotterdam Study, free of cardiovascular disease, who underwent IAD ultrasound assessment between 2009-2014. Linear regression analysis was used to identify determinants of IAD. The medians (inter-quartile range) of absolute IAD and body surface area (BSA)-adjusted IAD were 17.0 (15.0-18.0) mm and 9.3 (8.5-10.2) mm for women and 19.0 (18.0-21.0) mm and 9.4 (8.6-10.3) mm for men, respectively. There was a non-linear relationship between age and IAD. IAD increased steeply with advancing age and up to 70 years. After around 75 years of age, the diameter values reached a plateau. Waist circumference and diastolic blood pressure were associated with larger diameters in both sexes. Body mass index [Effect estimate (95% CI): 0.04 (0.00 to 0.08)], systolic blood pressure [- 0.01(- 0.02 to 0.00)], current smoking [0.35 (0.06 to 0.65)], total cholesterol levels [- 0.21 (- 0.31 to - 0.11)], and lipid-lowering medication [- 0.43 (- 0.67 to - 0.19)] were significantly associated with IAD in women. Sex differences in IAD values diminished after taking BSA into account. The increase in diameters was attenuated after 70 years. Differences were observed in the associations of several cardiovascular risk factors with IAD among men and women.
建立非动脉瘤性老年人群的肾下腹部腹主动脉直径（IAD）的年龄和性别特异性分布，并研究男女之间传统心血管危险因素与 IAD 之间的关系。
我们纳入了来自于人群基础的鹿特丹研究中的 4032 名参与者（平均年龄 67.2 岁，60.4%为女性），这些参与者无心血管疾病，于 2009-2014 年期间接受了 IAD 超声评估。线性回归分析用于确定 IAD 的决定因素。女性的绝对 IAD 和体表面积（BSA）校正 IAD 的中位数（四分位数范围）分别为 17.0（15.0-18.0）mm 和 9.3（8.5-10.2）mm，男性分别为 19.0（18.0-21.0）mm 和 9.4（8.6-10.3）mm。年龄与 IAD 之间存在非线性关系。IAD 随年龄的增长而急剧增加，直至 70 岁。大约 75 岁以后，直径值达到平台期。腰围和舒张压与两性的较大直径均相关。体重指数[效应估计值（95%可信区间）：0.04（0.00 至 0.08）]，收缩压[-0.01（-0.02 至 0.00）]，当前吸烟[0.35（0.06 至 0.65）]，总胆固醇水平[-0.21（-0.31 至-0.11）]和降脂药物[-0.43（-0.67 至-0.19）]与女性的 IAD 显著相关。考虑 BSA 后，IAD 值的性别差异减小。直径的增加在 70 岁以后减弱。在男性和女性中，几个心血管危险因素与 IAD 之间的关系存在差异。
