Guimarães Tarcísio Guerra, Marto Carlos Miguel, Cardoso Karla Menezes, Alexandre Nuno, Botelho Maria Filomena, Laranjo Mafalda
Institute for Advanced Studies and Research (IIFA), University of Évora, Portugal.
Institute of Agrarian and Environmental Sciences (ICAAM), University of Évora, Portugal.
Lab Anim. 2022 Apr;56(2):119-134. doi: 10.1177/00236772211039333. Epub 2021 Sep 9.
Melanomas are the most common cancer of the eye in canines, felines and humans. The treatment approaches vary, since no gold standard exists. Therefore, this systematic review aimed to compare the treatment modalities in ocular melanoma in rabbits. Medline/PubMed, Cochrane Library, Web of Science and Embase were searched for articles published until 21 April 2021 in English, Portuguese or Spanish, reporting animal studies evaluating photodynamic therapy (PDT), laser, radiotherapy or surgical excision. Twenty-seven articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT, six used radiotherapy and two used laser as treatment. No studies regarding surgical therapy that met the inclusion criteria were obtained. The tumour therapy results were evaluated in a heterogeneous manner for different periods and various methods, including microscopy, angiographic, histological examination, fundoscopy, ultrasound exam and electroretinogram. The treatment modalities analysed successfully treated the ocular melanoma, with tumour necrosis being commonly observed. Despite the therapeutic efficacy shown, side effects have been reported for all the therapies. The studies showed high heterogeneity, and therefore, in the future, new studies should be carried out to increase knowledge about ocular melanoma treatment. The analysed therapies can be used successfully in the treatment of ocular melanoma, with more conservative options such as PDT presenting great potential.
黑色素瘤是犬类、猫科动物和人类中最常见的眼部癌症。由于不存在金标准，治疗方法各不相同。因此，本系统评价旨在比较兔眼黑色素瘤的治疗方式。检索了Medline/PubMed、Cochrane图书馆、科学网和Embase，查找截至2021年4月21日以英文、葡萄牙文或西班牙文发表的报告动物研究的文章，这些研究评估了光动力疗法（PDT）、激光、放射疗法或手术切除。纳入27篇文章进行定性综合分析，发表日期为1970年至2018年。在所选研究中，19项使用了PDT，6项使用了放射疗法，2项使用了激光作为治疗方法。未获得符合纳入标准的关于手术治疗的研究。对不同时期和各种方法（包括显微镜检查、血管造影、组织学检查、检眼镜检查、超声检查和视网膜电图）的肿瘤治疗结果进行了异质性评估。所分析的治疗方式成功治疗了眼黑色素瘤，常见肿瘤坏死现象。尽管显示出治疗效果，但所有治疗方法均报告有副作用。研究显示出高度异质性，因此，未来应开展新的研究以增加对眼黑色素瘤治疗的了解。所分析的治疗方法可成功用于眼黑色素瘤的治疗，如PDT等更保守的选择具有很大潜力。
