Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, Addis Ababa, Ethiopia.
Biomed Res Int. 2021 Aug 30;2021:5539544. doi: 10.1155/2021/5539544. eCollection 2021.
Since 2000, a good deal of progress has been made in malaria control. However, there is still an unacceptably high burden of the disease and numerous challenges limiting advancement towards its elimination and ultimate eradication. Among the challenges is the antimalarial drug resistance, which has been documented for almost all antimalarial drugs in current use. As a result, the malaria research community is working on the modification of existing treatments as well as the discovery and development of new drugs to counter the resistance challenges. To this effect, many products are in the pipeline and expected to be marketed soon. In addition to drug and vaccine development, mass drug administration (MDA) is under scientific scrutiny as an important strategy for effective utilization of the developed products. This review discusses the challenges related to malaria elimination, ongoing approaches to tackle the impact of drug-resistant malaria, and upcoming antimalarial drugs.
自 2000 年以来，疟疾控制取得了很大进展。然而，该疾病的负担仍然高得令人无法接受，并且存在许多限制其消除和最终根除的挑战。其中的挑战之一是抗疟药物耐药性，几乎所有目前使用的抗疟药物都有耐药性的记录。因此，疟疾研究界正在努力改进现有的治疗方法，并发现和开发新的药物来应对耐药性的挑战。为此，许多产品正在研发中，预计很快将推向市场。除了药物和疫苗的开发，大规模药物管理（MDA）作为有效利用已开发产品的重要策略，也受到了科学界的关注。本文讨论了与疟疾消除相关的挑战、正在采取的方法来应对耐药性疟疾的影响，以及即将推出的抗疟药物。
