Newby Gretchen, Hwang Jimee, Koita Kadiatou, Chen Ingrid, Greenwood Brian, von Seidlein Lorenz, Shanks G Dennis, Slutsker Laurence, Kachur S Patrick, Wegbreit Jennifer, Ippolito Matthew M, Poirot Eugenie, Gosling Roly
Am J Trop Med Hyg. 2015 Jul;93(1):125-134. doi: 10.4269/ajtmh.14-0254. Epub 2015 May 26.
Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in specific settings.
群体服药（MDA）是疟疾根除时代许多疟疾防治项目的一个组成部分，但后来由于对其有效性和可行性的担忧以及对加速耐药性的恐惧，很少被采用。然而，最近，人们对群体服药作为一种消除疟疾的工具的作用重新产生了兴趣。在2013年Cochrane综述聚焦于疟疾群体服药的定量效果之后，我们对已发表、未发表和灰色文献进行了系统的定性综述，记录过去群体服药的经验。我们还咨询了实地专家，利用他们的历史经验，对群体服药在消除疟疾中的作用提供有见地的背景观点。仍然存在重大的知识空白，需要更多的研究，特别是关于最佳目标人群规模、提高覆盖率的方法以及伯氨喹的安全性。尽管存在这些空白，但群体服药过去已成功用于控制和消除恶性疟原虫和间日疟原虫疟疾，在特定环境下应被视为综合疟疾消除战略的一部分。
