Independent Researcher, Lancashire, Bolton BL2 3BG, UK.
School of Life Science, University of Dundee, Dundee DD1 5EH, UK.
Molecules. 2021 Aug 24;26(17):5129. doi: 10.3390/molecules26175129.
Gluconeogenesis is a key interface between organic acid/amino acid/lipid and sugar metabolism. The aims of this article are four-fold. First, to provide a concise overview of plant gluconeogenesis. Second, to emphasise the widespread occurrence of gluconeogenesis and its utilisation in diverse processes. Third, to stress the importance of the vacuolar storage and release of Krebs cycle acids/nitrogenous compounds, and of the role of gluconeogenesis and malic enzyme in this process. Fourth, to outline the contribution of fine control of enzyme activity to the coordinate-regulation of gluconeogenesis and malate metabolism, and the importance of cytosolic pH in this.
糖异生是有机酸/氨基酸/脂质和糖代谢之间的关键界面。本文的目的有四。首先，提供植物糖异生的简要概述。其次，强调糖异生的广泛存在及其在各种过程中的利用。第三，强调液泡储存和释放三羧酸循环酸/含氮化合物的重要性，以及糖异生和苹果酸酶在这一过程中的作用。第四，概述酶活性的精细控制对糖异生和苹果酸代谢的协调调节的贡献，以及细胞溶质 pH 在这方面的重要性。
