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白细胞介素 21 在病毒感染中的作用。

Interleukin-21 in Viral Infections.

机构信息

Department of Immunology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata City 990-9585, Japan.

出版信息

Int J Mol Sci. 2021 Sep 1;22(17):9521. doi: 10.3390/ijms22179521.

DOI:10.3390/ijms22179521
PMID:34502427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8430989/
Abstract

Interleukin (IL)-21 is a cytokine that affects the differentiation and function of lymphoid and myeloid cells and regulates both innate and adaptive immune responses. In addition to regulating the immune response to tumor and viral infections, IL-21 also has a profound effect on the development of autoimmune and inflammatory diseases. IL-21 is produced mainly from CD4 T cells-in particular, follicular helper T (Tfh) cells-which have a great influence on the regulation of antibody production. It is also an important cytokine for the activation of CD8 T cells, and its role in recovering the function of CD8 T cells exhausted by chronic microbial infections and cancer has been clarified. Thus, IL-21 plays an extremely important role in viral infections, especially chronic viral infections. In this review, I will introduce the findings to date on how IL-21 is involved in some typical viral infections and the potential of treating viral diseases with IL-21.

摘要

白细胞介素（IL）-21 是一种细胞因子，影响淋巴样和髓样细胞的分化和功能，并调节固有和适应性免疫反应。除了调节对肿瘤和病毒感染的免疫反应外，IL-21 对自身免疫和炎症性疾病的发展也有深远的影响。IL-21 主要由 CD4 T 细胞产生-特别是滤泡辅助 T（Tfh）细胞-对调节抗体产生有很大影响。它也是 CD8 T 细胞活化的重要细胞因子，其在恢复慢性微生物感染和癌症导致的耗尽的 CD8 T 细胞功能方面的作用已得到阐明。因此，IL-21 在病毒感染中起着极其重要的作用，尤其是慢性病毒感染。在这篇综述中，我将介绍迄今为止关于 IL-21 如何参与一些典型病毒感染以及用 IL-21 治疗病毒病的潜力的研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cc/8430989/d48f538690d4/ijms-22-09521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cc/8430989/dfb0decb65f8/ijms-22-09521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cc/8430989/d48f538690d4/ijms-22-09521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cc/8430989/dfb0decb65f8/ijms-22-09521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cc/8430989/d48f538690d4/ijms-22-09521-g002.jpg

相似文献

[1]
Interleukin-21 in Viral Infections.

Int J Mol Sci. 2021-9-1

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.

PLoS One. 2011-3-14

[10]
CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease.

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[8]
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[10]
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本文引用的文献

[1]
Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4 T cell help.

Cell Rep. 2021-6-29

[2]
IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques.

Nat Commun. 2021-5-17

[3]
Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency.

J Clin Immunol. 2021-8

[4]
Prior transient exposure to interleukin-21 delivered by recombinant adeno-associated virus vector protects mice from hepatitis B virus persistence.

Antiviral Res. 2021-6

[5]
Gamma-Chain Receptor Cytokines & PD-1 Manipulation to Restore HCV-Specific CD8 T Cell Response during Chronic Hepatitis C.

Cells. 2021-3-3

[6]
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.

Nat Commun. 2021-3-30

[7]
COVID-19 and the human innate immune system.

Cell. 2021-4-1

[8]
HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells.

AIDS. 2021-7-1

[9]
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

Nat Commun. 2021-2-24

[10]
IL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B.

Front Immunol. 2020

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