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宿主免疫与新生恒河猴感染 SHIV 后未经治疗的年轻恒河猴体内病毒血症的自发抑制有关。

Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection.

机构信息

Duke Human Vaccine Institute, Duke University School of Medicine , Durham, North Carolina, USA.

Children's Mercy Kansas City , Kansas City, Missouri, USA.

出版信息

J Virol. 2023 Nov 30;97(11):e0109423. doi: 10.1128/jvi.01094-23. Epub 2023 Oct 24.

DOI:10.1128/jvi.01094-23
PMID:37874153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10688376/
Abstract

Despite the advent of highly active anti-retroviral therapy, people are still dying from HIV-related causes, many of whom are children, and a protective vaccine or cure is needed to end the HIV pandemic. Understanding the nature and activation states of immune cell subsets during infection will provide insights into the immunologic milieu associated with viremia suppression that can be harnessed via therapeutic strategies to achieve a functional cure, but these are understudied in pediatric subjects. We evaluated humoral and adaptive host immunity associated with suppression of viremia in rhesus macaques infected soon after birth with a pathogenic SHIV. The results from our study provide insights into the immune cell subsets and functions associated with viremia control in young macaques that may translate to pediatric subjects for the design of future anti-viral strategies in HIV-1-infected infants and children and contribute to an understudied area of HIV-1 pathogenesis in pediatric subjects.

摘要

尽管出现了高效抗逆转录病毒疗法，但仍有人因与 HIV 相关的原因而死亡，其中许多是儿童，因此需要一种保护性疫苗或治疗方法来终结 HIV 大流行。了解感染期间免疫细胞亚群的性质和激活状态将为理解与病毒血症抑制相关的免疫环境提供线索，这些免疫环境可以通过治疗策略加以利用，从而实现功能性治愈，但这些在儿科研究对象中研究不足。我们评估了在恒河猴出生后不久感染致病性 SHIV 后与抑制病毒血症相关的体液和适应性宿主免疫。本研究的结果提供了与年轻恒河猴病毒血症控制相关的免疫细胞亚群和功能的见解，这些可能适用于儿科研究对象，用于设计针对 HIV-1 感染婴儿和儿童的未来抗病毒策略，并有助于研究儿童 HIV-1 发病机制中的一个研究不足的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/10688376/a178cb863a9a/jvi.01094-23.f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/10688376/131cda9567da/jvi.01094-23.f001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/10688376/a178cb863a9a/jvi.01094-23.f009.jpg
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