Noseda A, Carpiaux J P, Vandeput W, Prigogine T, Schmerber J
Hôpital Universitaire Brugmann, Bruxelles, Belgique.
Bull Eur Physiopathol Respir. 1987 Sep-Oct;23(5):457-63.
Twenty patients with stable COPD (mean age 67.8 yr; mean FEV1 1.08 1), all limited by ventilation at maximum exercise, were randomly allocated after a four week control period, to an eight week programme of either inspiratory resistive training (IRT), with a P Flex device, or conventional breathing retraining (BR). Exercise performance was evaluated every four weeks, using a 12-min walking test, an incremental progressive exercise on a cycle ergometer and a cycle endurance test. Inspiratory muscle endurance was measured as the highest tolerated resistance for 10 min on a P Flex device. IRT produced a significant (p less than 0.05) increase in the highest tolerated resistance, but IRT and BR failed to improve lung function or exercise performance. The present study shows that in COPD patients with ventilatory limitation on exercise an IRT programme may fail to improve exercise performance, in spite of an efficient training effect on the endurance of the inspiratory muscles.
20例稳定期慢性阻塞性肺疾病患者（平均年龄67.8岁；平均第1秒用力呼气容积为1.08升），所有患者在最大运动时均受通气限制，在为期4周的对照期后，被随机分配至为期8周的吸气阻力训练（IRT）方案组（使用P Flex装置）或传统呼吸再训练（BR）组。每4周使用12分钟步行试验、在自行车测力计上进行递增式渐进运动以及自行车耐力试验评估运动表现。吸气肌耐力通过在P Flex装置上耐受10分钟的最高阻力来测量。IRT使最高耐受阻力显著增加（p<0.05），但IRT和BR均未能改善肺功能或运动表现。本研究表明，在运动时存在通气限制的慢性阻塞性肺疾病患者中，尽管IRT方案对吸气肌耐力有有效的训练效果，但可能无法改善运动表现。
