De Lazzari Nico, Niels Timo, Tewes Mitra, Götte Miriam
Department of Medical Oncology, West German Cancer Center, University Hospital Essen, 45147 Essen, Germany.
Department I of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Düsseldorf, University Hospital of Cologne, 50937 Cologne, Germany.
Cancers (Basel). 2021 Sep 6;13(17):4478. doi: 10.3390/cancers13174478.
Exercise therapy is a common supportive strategy in curative cancer treatment with strong evidence regarding its positive effects on, for example, cancer-related fatigue, health- related quality of life, and physical function. In the field of advanced cancer patients, knowledge about exercise as a useful supportive strategy is missing. The aim of this systematic review was to evaluate the feasibility and safety of exercise interventions as well as its effects on lowering the symptom burden. We included randomized controlled trials and nonrandomized controlled trials with advanced cancer patients receiving any type of exercise intervention. After an extensive literature search (in accordance to PRIMSA guidelines) in PubMed, Cochrane Library, and SPORTDiscus, 14 studies including 940 participants with different cancer entities were eligible. The results indicated the safety of exercise. In total, 493 participants received exercise interventions, with nine adverse events and no severe adverse events. The median recruitment rate was 68.33%, and adherence to exercise intervention was 86%. Further research with a high-quality and larger sample size is needed to clarify the potential of exercise with advanced cancer patients. Different advanced cancer entities have distinguished symptoms, and future research should construct entities-specific trial populations to figure out the best supportive exercise interventions.
运动疗法是癌症治疗中一种常见的支持性策略，有充分证据表明其对癌症相关疲劳、健康相关生活质量和身体功能等具有积极影响。在晚期癌症患者领域，关于运动作为一种有用支持性策略的知识尚缺。本系统评价的目的是评估运动干预的可行性和安全性及其对减轻症状负担的影响。我们纳入了晚期癌症患者接受任何类型运动干预的随机对照试验和非随机对照试验。在按照PRISMA指南对PubMed、Cochrane图书馆和SPORTDiscus进行广泛文献检索后，14项研究符合要求，包括940名患有不同癌症类型的参与者。结果表明运动是安全的。共有493名参与者接受了运动干预，发生9起不良事件，无严重不良事件。招募率中位数为68.33%，运动干预依从率为86%。需要进行高质量、更大样本量的进一步研究，以阐明运动对晚期癌症患者的潜在作用。不同的晚期癌症类型有不同的症状，未来研究应构建特定癌症类型的试验人群，以找出最佳的支持性运动干预措施。
