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一种新型膳食补充剂的细胞毒性和抗炎特性评估

assessment of the cytotoxicity and anti-inflammatory properties of a novel dietary supplement.

作者信息

Popescu Ionela D, Codrici Elena, Mihai Simona, Luntraru Cristina-Mihaela, Neagu Mihaela, Tanase Cristiana

机构信息

Biochemistry-Proteomics Department, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.

Department of Research and Development Patents, SC Hofigal Export Import SA, 042124 Bucharest, Romania.

出版信息

Exp Ther Med. 2021 Oct;22(4):1170. doi: 10.3892/etm.2021.10604. Epub 2021 Aug 12.

DOI:10.3892/etm.2021.10604
PMID:34504615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8393499/
Abstract

Studies on the immunopharmacological activities of various plant species have provided evidence for the high therapeutic potential of different extracts. These represent a promising alternative to reduce the inflammatory processes and, thus, diseases related to inflammation. Numerous scientific studies strongly suggest that diet plays an essential role in inflammation, and that certain dietary factors can act as preventive or treatment methods to lower inflammation. In the present study, a novel lingonberry-based dietary supplement was investigated for the ability to suppress the inflammatory response in activated monocytes/macrophages. Based on cell viability/proliferation and cytotoxicity tests, concentrations between 40 and 130 µg/ml of the extracts showed a high viability/proliferation effect and no cytotoxic activity in monocyte/macrophage cells. To further investigate the anti-inflammatory potential of our novel lingonberry-based dietary supplement, we studied the effect of the extract on the inflammatory response in lipopolysaccharide (LPS)-stimulated macrophages. We found that the extract exhibited a strong anti-inflammatory potential by inhibiting the expression of major inflammatory cytokines [interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)α] in activated monocyte/macrophage cells. The expression of IL-6 and IL-8 was subsequently validated by enzyme-linked immunosorbent assay (ELISA). In conclusion, we demonstrated that our product exhibits no cytotoxicity and suppresses inflammation, and thus can be considered a natural important tool for inflammation control.

摘要

对各种植物物种免疫药理活性的研究为不同提取物的高治疗潜力提供了证据。这些提取物是减轻炎症过程以及与炎症相关疾病的一种有前景的替代方法。大量科学研究强烈表明，饮食在炎症中起重要作用，某些饮食因素可作为降低炎症的预防或治疗方法。在本研究中，对一种新型越橘基膳食补充剂抑制活化单核细胞/巨噬细胞炎症反应的能力进行了研究。基于细胞活力/增殖和细胞毒性测试，提取物浓度在40至130μg/ml之间时，在单核细胞/巨噬细胞中显示出高活力/增殖效应且无细胞毒性活性。为进一步研究我们新型越橘基膳食补充剂的抗炎潜力，我们研究了该提取物对脂多糖（LPS）刺激的巨噬细胞炎症反应的影响。我们发现该提取物通过抑制活化单核细胞/巨噬细胞中主要炎症细胞因子[白细胞介素（IL）-6、IL-8和肿瘤坏死因子（TNF）α]的表达，表现出强大的抗炎潜力。随后通过酶联免疫吸附测定（ELISA）验证了IL-6和IL-8的表达。总之，我们证明了我们的产品无细胞毒性且能抑制炎症，因此可被视为控制炎症的一种重要天然工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/e2104fa644e5/etm-22-04-10604-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/7bc182e77be2/etm-22-04-10604-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/3120955e229f/etm-22-04-10604-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/da78a6371b71/etm-22-04-10604-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/efa2c7a2b1b8/etm-22-04-10604-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/ab2f4d0d47b7/etm-22-04-10604-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/71a7c99fa6bf/etm-22-04-10604-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/e2104fa644e5/etm-22-04-10604-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/7bc182e77be2/etm-22-04-10604-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/3120955e229f/etm-22-04-10604-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/da78a6371b71/etm-22-04-10604-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/efa2c7a2b1b8/etm-22-04-10604-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/ab2f4d0d47b7/etm-22-04-10604-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/71a7c99fa6bf/etm-22-04-10604-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ba/8393499/e2104fa644e5/etm-22-04-10604-g06.jpg

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