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2021 年 6 月，比利时 ST1486 中出现新型万古霉素耐药基因簇。

Novel vancomycin resistance gene cluster in ST1486, Belgium, June 2021.

机构信息

Laboratory of Medical Microbiology, Universiteit Antwerpen, Wilrijk, Belgium.

Vaccine and Infectious Disease Institute, Universiteit Antwerpen, Wilrijk, Belgium.

出版信息

Euro Surveill. 2021 Sep;26(36). doi: 10.2807/1560-7917.ES.2021.26.36.2100767.

DOI:10.2807/1560-7917.ES.2021.26.36.2100767
PMID:34505571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8431993/
Abstract

We identified a novel gene cluster in a clinical isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, , was part of a operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from and sp. 499. Screening for genes in strains with borderline susceptibility to vancomycin is important.

摘要

我们从一个万古霉素最低抑菌浓度（MIC）为 4μg/ml 的临床分离株中鉴定出一个新型基因簇。连接酶基因，位于一个假定的新型整合性接合元件上，该元件位于一个约 98kb 的基因组区域内，可能是通过水平基因转移从 和 sp. 499 获得的，该 operon 簇长 4589bp。对具有万古霉素临界敏感性的 菌株进行 基因筛查非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/f3c1050f98d8/2100767-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/3dc3a3241e3d/2100767-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/b9d299e1c759/2100767-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/ea62f7722c8d/2100767-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/f3c1050f98d8/2100767-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/3dc3a3241e3d/2100767-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/b9d299e1c759/2100767-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/ea62f7722c8d/2100767-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41c/8431993/f3c1050f98d8/2100767-f4.jpg

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