Nobel Medical College Teaching Hospital, Biratnagar, Morang, Nepal.
Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2022 Mar 11;60(247):241-245. doi: 10.31729/jnma.7321.
Acute ischemic stroke is the second most common cause of death after ischemic heart disease worldwide and Nepal's top five diseases based on Disability-Adjusted Life Years. Dyslipidemia is a major risk factor for coronary heart disease but has an unclear role in the pathogenesis of ischemic stroke. The objective of this study was to find the prevalence of dyslipidemia in acute non-cardioembolic ischemic stroke patients at a tertiary care centre.
A descriptive cross-sectional study was conducted among 76 patients with acute noncardioembolic ischemic stroke admitted in the Neuromedicine unit of a tertiary care centre from August 2017 to July 2018. Ethical approval was obtained from the Institutional Review Committee of the same institute (Reference number: 478/2020). Patients underwent baseline investigations, including fasting lipid profile and Computed Tomography Scan/Magnetic Resonance Imaging head. Data were analysed using Statistical Package for the Social Sciences version 21.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.
The prevalence of dyslipidemia among the acute non-cardioembolic ischemic stroke patients was 35 (46.05%) (35.05-57.05 at 95% Confidence Interval) where high total cholesterol was diagnosed in 11 (31.43%), high triglycerides in 25 (71.43%), high low-density-lipoprotein in 10 (28.57%), and low high-density-lipoprotein in 11 (31.43%) patients.
The prevalence of dyslipidemia among acute non-cardioembolic ischemic stroke patients at our tertiary care centre is higher than the similar studies done in similar settings.
cardioembolic stroke; dyslipidemia; ischemic stroke; lipid; lipoprotein.
急性缺血性脑卒中是全球继缺血性心脏病之后的第二大致死病因，也是尼泊尔基于伤残调整生命年的前五大疾病。血脂异常是冠心病的主要危险因素，但在缺血性脑卒中的发病机制中作用尚不清楚。本研究旨在探讨三级保健中心急性非心源性缺血性脑卒中患者血脂异常的患病率。
本研究为描述性横断面研究，纳入了 2017 年 8 月至 2018 年 7 月在三级保健中心神经医学科住院的 76 例急性非心源性缺血性脑卒中患者。本研究获得了同一机构的伦理审查委员会的批准（编号：478/2020）。患者接受了基线检查，包括空腹血脂谱和计算机断层扫描/磁共振成像头部检查。使用社会科学统计软件包 21.0 进行数据分析。计算了 95%置信区间的点估计值，以及二分类数据的频率和比例。
急性非心源性缺血性脑卒中患者血脂异常的患病率为 35 例（46.05%）（95%置信区间为 35.05-57.05），其中高总胆固醇 11 例（31.43%），高三酰甘油血症 25 例（71.43%），高低密度脂蛋白血症 10 例（28.57%），低高密度脂蛋白血症 11 例（31.43%）。
我们的三级保健中心急性非心源性缺血性脑卒中患者血脂异常的患病率高于类似环境下的类似研究。
心源性脑栓塞；血脂异常；缺血性脑卒中；血脂；脂蛋白。
