Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangzhou 510515, China.
Shenzhen Luohu People's Hospital, Shenzhen 518000, China.
Adv Drug Deliv Rev. 2021 Nov;178:113967. doi: 10.1016/j.addr.2021.113967. Epub 2021 Sep 10.
Graphene oxide (GO), for its unique structure with high biocompatibility and designability, is widely used in the antibacterial field. Various strategies have been designed to fabricate GO-based composites with antibacterial properties. This review summarized these strategies, divided them into three types and interpreted their antibacterial mechanisms: (i) "GO*/non-GO" type in which GO acts as the single antibacterial core, (ii) "GO*/non-GO*" type in which GO and non-GO components function synergistically as dual antibacterial cores, (iii) "GO/non-GO*" type in which non-GO acts as the single antibacterial core, while GO component plays a supportive, not a dominant role in antibiosis. Besides, the fields suiting their applications and factors influencing their antibacterial properties were analyzed. Finally, the limitations and prospects in the current researches were discussed. In summary, GO-based composites have revolutionized antibacterial strategies. This review may serve as a reference to inspire further research on GO-based antibacterial composites.
氧化石墨烯（GO）具有独特的结构，具有高生物相容性和可设计性，因此被广泛应用于抗菌领域。人们设计了各种策略来制备具有抗菌性能的 GO 基复合材料。本综述总结了这些策略，将它们分为三类，并解释了它们的抗菌机制：（i）“GO*/非 GO”型，其中 GO 作为单一的抗菌核心，（ii）“GO*/非 GO*”型，其中 GO 和非 GO 成分协同作为双抗菌核心，（iii）“GO/非 GO*”型，其中非 GO 作为单一的抗菌核心，而 GO 成分在抗菌作用中起支持作用，而不是主导作用。此外，还分析了它们适合应用的领域以及影响它们抗菌性能的因素。最后，讨论了目前研究中的局限性和前景。总之，基于 GO 的复合材料彻底改变了抗菌策略。本综述可以作为参考，激发对基于 GO 的抗菌复合材料的进一步研究。
