Shibata Teishiki, Hashimoto Nobukazu, Okura Atsuhiko, Mase Mitsuhito
Department of Neurosurgery, Nagoya City University West Medical Center, Nagoya, Japan.
Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan.
Surg Neurol Int. 2021 Aug 16;12:417. doi: 10.25259/SNI_541_2021. eCollection 2021.
Oral infection and dental manipulations can lead to the development of brain abscesses, a rare but potentially life-threatening condition. Herein, we report patients undergoing cancer treatment who developed brain abscesses of odontogenic origin at our hospital.
Two patients developed brain abscesses during cancer treatment. Both underwent neurosurgical aspiration, and the causative microorganism was identified as of the group, which is a part of the normal bacterial flora in the oral cavity. There was clinical and radiographic evidence of dental infection in one of the patients diagnosed with a brain abscess of odontogenic origin. No infectious foci were found in the other patient during hospitalization for the abscess. However, the patient had undergone extraction of an infected tooth approximately 3 months before admission for the abscess, suggesting origination from an oral infection or dental manipulation. The patients' cancers rapidly worsened because cancer treatment in both patients was interrupted for several months to treat the brain abscess.
Oral infections can cause severe infections, such as brain abscesses, particularly during the treatment of malignant tumors. Improving the oral environment or treating oral infections before initiating treatment for malignant tumors is highly recommended. In addition, the possibility of odontogenic origin should always be considered as a potential etiology of brain abscesses.
口腔感染和牙科操作可导致脑脓肿的发生，这是一种罕见但可能危及生命的病症。在此，我们报告我院收治的癌症治疗期间发生牙源性脑脓肿的患者。
两名患者在癌症治疗期间发生脑脓肿。两人均接受了神经外科穿刺抽吸，致病微生物被鉴定为 组，它是口腔正常细菌菌群的一部分。在诊断为牙源性脑脓肿的其中一名患者中，有牙科感染的临床和影像学证据。在另一名因脓肿住院的患者中，住院期间未发现感染灶。然而，该患者在因脓肿入院前约3个月拔除了一颗感染牙，提示源于口腔感染或牙科操作。由于两名患者的癌症治疗均中断数月以治疗脑脓肿，其癌症迅速恶化。
口腔感染可导致严重感染，如脑脓肿，尤其是在恶性肿瘤治疗期间。强烈建议在开始恶性肿瘤治疗前改善口腔环境或治疗口腔感染。此外，应始终将牙源性起源的可能性视为脑脓肿的潜在病因。
