Irwin M, Daniels M, Smith T L, Bloom E, Weiner H
Clinical Center on Alcoholism, Veterans Administration Medical Center, San Diego, California 92161.
Brain Behav Immun. 1987 Mar;1(1):98-104. doi: 10.1016/0889-1591(87)90011-0.
Natural killer (NK) cell activity, a component of the immune surveillance system, was compared in women whose husbands had recently died with that found in age-matched women who had not experienced recent adverse life events. Bereaved women had significantly lower NK activity than women whose husbands were healthy. In a second study, depressive symptoms and NK activity were measured longitudinally in women before and after the death of their husbands. Our results suggest that depressive symptoms, not merely the death of the spouse, are related to a reduction in NK activity during bereavement.
自然杀伤（NK）细胞活性是免疫监视系统的一个组成部分，我们对近期丈夫去世的女性的NK细胞活性与年龄匹配的、近期未经历不良生活事件的女性的NK细胞活性进行了比较。丧偶女性的NK细胞活性显著低于丈夫健康的女性。在第二项研究中，我们对女性在丈夫去世前后的抑郁症状和NK细胞活性进行了纵向测量。我们的结果表明，在居丧期间，与NK细胞活性降低相关的是抑郁症状，而不仅仅是配偶的死亡。
