Department of Inorganic Chemistry-Functional Materials, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.
Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.
Angew Chem Int Ed Engl. 2021 Oct 11;60(42):22700-22705. doi: 10.1002/anie.202108378. Epub 2021 Sep 14.
Self-assembly processes guide disordered molecules or particles into long-range organized structures due to specific supramolecular interactions among the building entities. Herein, we report a unique evaporation-induced self-assembly (EISA) strategy for four different silica nanoparticle systems obtained through peptide functionalization of the particle surface. First, covalent peptide-silica coupling was investigated in detail, starting with the grafting of a single amino acid (L-serine) and expanded to specific small peptides (up to four amino acids) and transferred to different particle types (MCM-48-type MSNs, solid nanoparticles, and newly developed virus-like nanoparticles). These materials were investigated regarding their ability to undergo EISA, which was shown to be independent of particle type and amount of peptide anchored to their surface. This EISA-based approach provides new possibilities for the design of future advanced drug delivery systems, engineered hierarchical sorbents, and nanocatalyst assemblies.
自组装过程由于构建单元之间的特定超分子相互作用，将无序的分子或颗粒引导成长程有序的结构。在此，我们报告了一种独特的蒸发诱导自组装（EISA）策略，用于通过颗粒表面的肽功能化获得的四个不同的二氧化硅纳米颗粒系统。首先，详细研究了共价肽-硅偶联，从单个氨基酸（L-丝氨酸）的接枝开始，扩展到特定的小肽（最多四个氨基酸），并转移到不同的颗粒类型（MCM-48 型 MSNs、实心纳米颗粒和新开发的类病毒纳米颗粒）。研究了这些材料进行 EISA 的能力，结果表明，EISA 与颗粒类型以及固定在其表面的肽的量无关。这种基于 EISA 的方法为未来先进药物输送系统、工程分级吸附剂和纳米催化剂组件的设计提供了新的可能性。
