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在毛囊形态发生和诱导的毛发周期中 Sox10 的表达和定位。

Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle.

机构信息

Department of Dermatology, the second affiliated hospital of Zhejiang University, Hangzhou 310000, China.

Department of Neuro intensive Care Unit, the second affiliated hospital of Zhejiang University, Hangzhou 310000, China.

出版信息

Int J Med Sci. 2021 Aug 13;18(15):3498-3505. doi: 10.7150/ijms.60728. eCollection 2021.

DOI:10.7150/ijms.60728
PMID:34522176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8436095/
Abstract

Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape. Sox10 has been implicated in the control of stem/progenitor activity and epithelial-mesenchymal transition, yet it has not been studied in relation to the hair follicle cycle or hair follicle stem cell (HFSC) control. To elucidate the role of Sox10 in hair follicle cycle control, we performed immunohistochemical and immunofluorescence analysis of its expression during hair morphogenesis, the postnatal hair cycle, and the depilation-induced murine hair follicle cycle. During hair follicle morphogenesis, Sox10 was expressed in the hair germ and peg. In telogen, we detected nuclear Sox10 in the hair bulge and germ cell cap, where HFSCs reside, while in anagen and catagen, Sox10 was detected in the epithelial portion, such as the strands of keratinocytes, the outer root sheath (ORS) in anagen, and the regressed epithelial strand of hair follicle in catagen. These results suggest that Sox10 may be involved in early hair follicle morphogenesis and postnatal follicular cycling.

摘要

Sox 转录因子在发育过程中发挥着多种不同的作用，包括调节干细胞状态、指导分化以及影响局部染色质景观。 Sox10 已被牵涉到干细胞/祖细胞活性和上皮-间充质转化的控制中，但尚未研究其与毛囊周期或毛囊干细胞 (HFSC) 控制的关系。为了阐明 Sox10 在毛囊周期控制中的作用，我们在毛囊形态发生、出生后毛发周期和脱毛诱导的小鼠毛囊周期期间进行了 Sox10 表达的免疫组织化学和免疫荧光分析。在毛囊形态发生过程中， Sox10 在毛囊芽和钉中表达。在休止期，我们在毛囊隆起和生殖细胞帽中检测到核 Sox10，HFSCs 就位于此处，而在生长期和退行期， Sox10 则在表皮部分（如角质形成细胞的链、生长期的外根鞘 (ORS) 和退行期的毛囊上皮链）中检测到。这些结果表明 Sox10 可能参与早期毛囊形态发生和出生后毛囊周期性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/b184b0b83ad1/ijmsv18p3498g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/782c877b9b12/ijmsv18p3498g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/6be1b9da142f/ijmsv18p3498g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/6055b14d6177/ijmsv18p3498g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/4c58b17bcc66/ijmsv18p3498g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/b184b0b83ad1/ijmsv18p3498g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/782c877b9b12/ijmsv18p3498g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/6be1b9da142f/ijmsv18p3498g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/6055b14d6177/ijmsv18p3498g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/4c58b17bcc66/ijmsv18p3498g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d04/8436095/b184b0b83ad1/ijmsv18p3498g005.jpg

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