Liu Yichen, Zhao Qiong, Xi Tao, Zheng Lufeng, Li Xiaoman
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210023, PR China.
School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 639 Longmian Road, Nanjing, Jiangsu Province, 211198, PR China.
Genes Dis. 2020 Oct 23;8(6):759-768. doi: 10.1016/j.gendis.2020.10.005. eCollection 2021 Nov.
Metastasis, is a development of secondary tumor growths at a distance from the primary site, and closely related to poor prognosis and mortality. However, there is still no effective treatment for metastatic cancer. Therefore, there is an urgent need to find an effective therapy for cancer metastasis. Plenty of evidence indicates that miR-9 can function as a promoter or suppressor in cancer metastasis and coordinate multistep of metastatic process. In this review, we summarize the different roles of miR-9 with the corresponding molecular mechanisms in metastasis of twelve common cancers and the multiple mechanisms underlying miR-9-mediated regulation of metastasis, benefiting the further research of miR-9 and metastasis, and hoping to bridge it with clinical applications.
转移是指在远离原发部位处发生继发性肿瘤生长，与预后不良和死亡率密切相关。然而，对于转移性癌症仍没有有效的治疗方法。因此，迫切需要找到一种治疗癌症转移的有效疗法。大量证据表明，miR-9在癌症转移中可发挥促进或抑制作用，并协调转移过程的多个步骤。在本综述中，我们总结了miR-9在十二种常见癌症转移中的不同作用及其相应的分子机制，以及miR-9介导转移调控的多种机制，这有助于对miR-9与转移进行进一步研究，并希望将其与临床应用联系起来。
