Klaschik Sven, Ellerkmann Richard K, Gehlen Jennifer, Frede Stilla, Hilbert Tobias
Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Department of Anesthesiology and Intensive Care Medicine, Dortmund Hospital, Beurhausstrasse 40, 44137 Dortmund, Germany.
Open Life Sci. 2021 Aug 28;16(1):872-883. doi: 10.1515/biol-2021-0089. eCollection 2021.
Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rather improves the properties of in several ways. A translational approach, including (I) experiments, (II) a randomized, blinded crossover trial of acute clinical effects, and (III) a standardized red wine blind tasting was used. Three monovarietal wines (Cabernet Sauvignon, Chianti, Shiraz) in three different vintages (range 2004-2016), each 5 years different, were assessed. Assessments were performed at a German university hospital (I, II) and on a garden terrace during a mild summer evening (III). Young wines induced cell stress and damage while significantly reducing cytoprotective proteins in HepG2 hepatoma cells. Sympathetic activity and multitasking skills were altered depending on wines' ages. Hangovers tended to be aggravated by young red wine. Aged variants performed better in terms of aroma and overall quality but worse in optical appearance. We found no evidence for a . However, we plead for consensus-based guidelines for proper storage, as it is common in clinical medicine.
像红细胞浓缩液和红酒这样极其重要的红色液体在长期储存时质量会受到严重影响。就红细胞浓缩液而言，其结果在围手术期医学中具有特殊意义。相比之下，我们假设老化反而会在几个方面改善红酒的特性。我们采用了一种转化研究方法，包括（I）体外实验、（II）一项关于急性临床效果的随机、双盲交叉试验以及（III）一项标准化的红酒盲品试验。我们评估了三种不同年份（跨度为2004年至2016年，每隔5年一个年份）的三种单一品种葡萄酒（赤霞珠、基安蒂、设拉子）。评估分别在一家德国大学医院进行（I、II）以及在一个温和夏夜的花园露台上进行（III）。年轻葡萄酒会引发细胞应激和损伤，同时显著降低肝癌细胞系HepG2中的细胞保护蛋白。交感神经活动和多任务处理能力会因葡萄酒的年份不同而改变。年轻的红酒往往会加重宿醉症状。年份久的葡萄酒在香气和整体品质方面表现更好，但在外观方面表现较差。我们没有发现[此处原文缺失具体内容]的证据。然而，我们呼吁制定基于共识的妥善储存指南，因为这在临床医学中很常见。
