SARS-CoV-2 基因组中的遗传漂变及其对全球健康的影响。
Genetic drift in the genome of SARS COV-2 and its global health concern.
机构信息
Department of Microbiology, The University of Haripur, Haripur, Pakistan.
Department of Microbiology, Quaid I Azam University, Islamabad, Pakistan.
出版信息
J Med Virol. 2022 Jan;94(1):88-98. doi: 10.1002/jmv.27337. Epub 2021 Sep 23.
Abstract
The outbreak of the current coronavirus disease (COVID-19) occurred in late 2019 and quickly spread all over the world. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to a genetically diverse group that mutates continuously leading to the emergence of multiple variants. Although a few antiviral agents and anti-inflammatory medicines are available, thousands of individuals have passed away due to emergence of new viral variants. Thus, proper surveillance of the SARS-CoV-2 genome is needed for the rapid identification of developing mutations over time, which are of the major concern if they occur specifically in the surface spike proteins of the virus (neutralizing analyte). This article reviews the potential mutations acquired by the SARS-CoV2 since the pandemic began and their significant impact on the neutralizing efficiency of vaccines and validity of the diagnostic assays.
摘要
当前的冠状病毒病（COVID-19）疫情于 2019 年末爆发，并迅速蔓延至全球。严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）属于一个遗传多样性不断变异的群组，导致多种变体的出现。尽管有一些抗病毒药物和抗炎药物可用，但由于新病毒变体的出现，仍有成千上万的人死亡。因此，需要对 SARS-CoV-2 基因组进行适当监测，以便及时发现随时间推移而发生的发展性突变，如果这些突变特别出现在病毒的表面刺突蛋白（中和分析物）上，则尤为重要。本文综述了自疫情开始以来 SARS-CoV2 获得的潜在突变及其对疫苗中和效率和诊断检测有效性的重大影响。
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