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从犬皮肤和耳道中分离的粘红酵母的分子分型和抗真菌药敏谱。

Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal.

机构信息

Veterinary Dermatology, Nihon University College of Bioresource Sciences, 1866 Kameino, Fusisawa, Kanagawa 252-0880, Japan.

Dermatology Services for Dogs and Cats, 1F Tandem Hirano Bldg. 2-11-14, Hirano, Koto-ku, Tokyo 135-0023, Japan.

出版信息

J Vet Med Sci. 2021 Oct 5;83(10):1545-1548. doi: 10.1292/jvms.21-0361. Epub 2021 Sep 14.

DOI:10.1292/jvms.21-0361
PMID:34526416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8569882/
Abstract

Rhodotorula mucilaginosa are saprophytic yeast, and opportunistic infections known as human rhodotorulosis are increasing in immunocompromised patients. In this study, we isolated R. mucilaginosa from pet dogs in Japan and determined the minimum inhibitory concentrations (MICs) of antifungal drugs on these isolates to investigate the drug susceptibility pattern. All 10 isolates according to the broth microdilution (BM) assay of the Clinical and Laboratory Standards Institute (CLSI) M27-A2 were resistance to azoles and genetically close to fluconazole (FLZ)-resistant human isolates of R. mucilaginosa. Due to resistance, it is expected that treatment will be difficult if they infect humans.

摘要

胶红酵母是一种腐生酵母，在免疫功能低下的患者中，机会性感染被称为人体粘红酵母病，其发病率正在增加。在这项研究中，我们从日本的宠物犬中分离出胶红酵母，并测定了这些分离株对各种抗真菌药物的最小抑菌浓度（MIC），以研究其药敏模式。根据临床和实验室标准协会（CLSI）M27-A2 的肉汤微量稀释（BM）检测，所有 10 株分离株均对唑类药物耐药，且与氟康唑（FLZ）耐药的人体胶红酵母分离株遗传关系密切。由于耐药性的存在，如果这些酵母感染人类，预计治疗将很困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e0a/8569882/bea59bf6e128/jvms-83-1545-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e0a/8569882/bea59bf6e128/jvms-83-1545-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e0a/8569882/bea59bf6e128/jvms-83-1545-g001.jpg

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