大脑中记忆存储的表观遗传学
The epigenetics of memory storage in the brain.
作者信息
Parrish R Ryley, Gupta Swati, Lubin Farah D
机构信息
Department of Neurobiology, Evelyn F. McKnight Brain institute, The University of Alabama at Birmingham, Birmingham AL 35294-2182, USA.
出版信息
Cellscience. 2010 Jul;7(1):1-8.
Abstract
Epigenetics has been proposed as a molecular mechanism involved in encoding long-term memories. Specifically DNA methylation, an epigenetic mechanism thought to be static following cell differentiation, has been implicated as a dynamic transcription regulatory mechanism underlying the process of longterm memory storage. Now recent findings published in explore the possibility that stable DNA methylation changes within the cortex contributes to memory maintenance.
摘要
表观遗传学已被提出作为一种参与编码长期记忆的分子机制。具体而言，DNA甲基化作为一种在细胞分化后被认为是静态的表观遗传机制，已被认为是长期记忆存储过程中潜在的动态转录调控机制。最近发表的研究结果探讨了大脑皮层内稳定的DNA甲基化变化有助于记忆维持的可能性。
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