Departments of, Urology and Pediatric Urology.
Microbiology and Virology No. 1, Rostov State Medical University, Rostov-on-Don, Russia.
Int J Urol. 2021 Dec;28(12):1254-1259. doi: 10.1111/iju.14685. Epub 2021 Sep 15.
To explore the influence of the microbiota of prostate secretion on the clinical status of patients with chronic bacterial prostatitis.
This was an observational, single-center, comparative study. We evaluated the survey cards of 230 outpatients aged 18-45 years with a history of prostatitis from 2012 to 2019. As a result, 170 outpatients were selected for the study. All patients underwent an assessment of symptoms using International Prostate Symptom Score-quality of life, National Institutes of Health-Chronic Prostatitis Symptom Index, International Index of Erectile Function, pain visual analog scale. A bacteriological study (after the Meares-Stamey test) of post-massage urine was carried out on an extended media set. The following parameters were determined in each patient: leukocyturia and bacteriuria, serum testosterone and total prostate-specific antigen levels. Uroflowmetry, transrectal prostate ultrasound with color duplex mapping and ejaculate analysis were also carried out.
Aerobic-anaerobic bacterial associations were identified in all patients. Three comparison groups were identified depending on the microbiota's spectrum (in post-massage urine): aerobes prevailed in group 1 (n = 67), anaerobes prevailed in group 2 (n = 33), and the levels of aerobic and anaerobic bacteriuria were higher than ≥10 colony-forming units per mL in group 3 (n = 70). It was found that the severity of clinical symptoms (urination disorders, sexual dysfunction etc.) of chronic bacterial prostatitis, laboratory and instrumental changes (testosterone, prostate-specific antigen, prostate volume etc.) in groups 2 and 3 were significantly higher than in group 1.
In patients with chronic bacterial prostatitis, a predominance of anaerobes or a combination of aerobes and anaerobes in a titer of ≥10 colony-forming units per mL in post-massage urine is associated with worse clinical status.
探讨前列腺分泌物微生物群对慢性细菌性前列腺炎患者临床状况的影响。
这是一项观察性、单中心、对照研究。我们评估了 2012 年至 2019 年期间 230 名 18-45 岁前列腺炎门诊患者的调查卡，结果选择了 170 名患者进行研究。所有患者均采用国际前列腺症状评分-生活质量、美国国立卫生研究院-慢性前列腺炎症状指数、国际勃起功能指数、疼痛视觉模拟量表进行症状评估。对按摩后尿液进行扩展介质培养的细菌学研究（Meares-Stamey 试验后）。在每个患者中确定以下参数：白细胞尿和菌尿、血清睾酮和总前列腺特异性抗原水平。还进行了尿流率、经直肠前列腺超声彩色双功图和精液分析。
在所有患者中均发现需氧-厌氧细菌联合。根据微生物群的谱（按摩后尿液）确定了三个比较组：组 1（n=67）以需氧菌为主，组 2（n=33）以厌氧菌为主，组 3（n=70）的需氧和厌氧菌菌尿水平高于≥10 个菌落形成单位/ml。结果发现，慢性细菌性前列腺炎的临床症状严重程度（排尿障碍、性功能障碍等）、实验室和仪器改变（睾酮、前列腺特异性抗原、前列腺体积等）在组 2 和组 3 中明显高于组 1。
在慢性细菌性前列腺炎患者中，按摩后尿液中厌氧菌占优势或需氧菌和厌氧菌联合占优势，且菌尿水平≥10 个菌落形成单位/ml 与更差的临床状况相关。
