Selenium-Enriched Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Regulating Inflammatory Cytokines and Intestinal Microbiota.

To evaluate the effect of Selenium-enriched (Se-enriched ) on dextran sulfate sodium (DSS)-induced colitis in mice. Mice were randomly divided into four groups: a control group, a control + Se-enriched group, a chronic colitis group, and a chronic colitis + Se-enriched group ( = 10 each group). The mice were sacrificed on the 26th day. The disease activity index, survival rates, and histological injury score were determined. Cytokines produced by lamina propria lymphocytes (LPLs), the selenium (Se) concentrations in serum and colon tissue and the mouse intestinal microbiota were evaluated. Se-enriched can improve histological injury and the disease activity index in mice with chronic colitis and reduce IL-1β, IL-6, IL-12p70, TNF-α, IL-23, IFN-γ, IL-17A, and IL-21 ( < 0.05) and increase IL-10 ( < 0.05) expression levels. Moreover, Se-enriched can increase the β diversity of intestinal microbiota in mice with chronic colitis, significantly reduce the relative abundance of and ( < 0.05), and significantly increase the relative abundance of ( < 0.05). Se-enriched can improve DSS-induced chronic colitis by regulating inflammatory cytokines and intestinal microbiota.