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运动可改善成人高级和低级胶质瘤患者健康相关生活质量的睡眠和疲劳领域。

Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients.

机构信息

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.

Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E Eisenhower Pkwy, Ste 100, Ann Arbor, MI, USA.

出版信息

Support Care Cancer. 2022 Feb;30(2):1493-1500. doi: 10.1007/s00520-021-06566-2. Epub 2021 Sep 16.

DOI:10.1007/s00520-021-06566-2
PMID:34532753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10182824/
Abstract

PURPOSE

The impact of exercise on health-related quality of life (HRQOL) in patients with glioma remains unknown. We hypothesized that glioma patients with low exercise tolerance experience more distress in HRQOL sleep and fatigue domains than patients with high tolerance to exercise.

METHODS

Thirty-eight male and female patients with low- or high-grade glioma treated at a single tertiary care institution participated. Patients completed a validated telephone survey to determine their exercise habits before and following diagnosis. An unpaired t-test was run to measure the interaction between exercise tolerances on HRQOL functional and impairment domains.

RESULTS

Those with low pre-morbid physical activity levels had more distress in HRQOL sleep and fatigue domains. The effects were independent of plasma brain-derived neurotrophic factor (BDNF) levels and the degree of exercise did not appear to impact plasma BDNF in adult glioma patients.

CONCLUSIONS

The aim of this study was to examine the significance of exercise habits on perioperative functional outcomes in patients with low-grade or high-grade glioma. We found that glioma patients with low tolerance to exercise had more sleep disturbances and greater fatigue than glioma patients with high tolerance to exercise. Furthermore, exercise tolerance in the adult glioma population does not appear to impact plasma BDNF secretion.

摘要

目的

运动对脑胶质瘤患者健康相关生活质量（HRQOL）的影响尚不清楚。我们假设低运动耐量的脑胶质瘤患者在 HRQOL 睡眠和疲劳领域比高运动耐量的患者感到更多的困扰。

方法

38 名男性和女性低级别或高级别脑胶质瘤患者在一家三级医疗机构接受治疗。患者完成了一项经过验证的电话调查，以确定他们在诊断前后的运动习惯。进行了独立样本 t 检验，以测量运动耐量与 HRQOL 功能和损伤领域之间的相互作用。

结果

那些有低发病前体力活动水平的患者在 HRQOL 睡眠和疲劳领域有更多的困扰。这些影响独立于血浆脑源性神经营养因子（BDNF）水平，而且运动的程度似乎不会影响成年脑胶质瘤患者的血浆 BDNF。

结论

本研究旨在检查运动习惯对低级别或高级别脑胶质瘤患者围手术期功能结果的意义。我们发现，运动耐量低的脑胶质瘤患者比运动耐量高的脑胶质瘤患者睡眠障碍更多，疲劳感更强。此外，成年脑胶质瘤人群的运动耐量似乎不会影响血浆 BDNF 的分泌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ab/10182824/4688ce6a8759/nihms-1895164-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ab/10182824/1c9e7f866db5/nihms-1895164-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ab/10182824/4688ce6a8759/nihms-1895164-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ab/10182824/1c9e7f866db5/nihms-1895164-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ab/10182824/4688ce6a8759/nihms-1895164-f0002.jpg

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