Li Peng, Chen Yan, Tang An, Gao Fan, Yan Jian-Bo
Zhoushan Municipal Center for Disease Control and Prevention, No.568 Wengshan Road, Zhoushan City, Zhejiang Province, 316021, People's Republic of China.
Department of Ophthalmology, Zhoushan Hospital, Zhoushan City, Zhejiang Province, 316021, People's Republic of China.
Arch Public Health. 2021 Sep 17;79(1):166. doi: 10.1186/s13690-021-00688-z.
Coxsackie virus group A type 16 (CoxA16) is the main pathogen and usually an alternative to or joins in prevalence with enterovirus 71 (EV71) causing hand, foot and mouth disease (HFMD). The objective of this study was to estimate the seroprevalence of CoxA16 antibody among people of various age groups by a systematic review and meta-analysis.
The literature of seroprevalence of CoxA16 antibody among people has been systematically searched through databases from the date of their establishment to Jan. 2021. Estimates of seroprevalence of CoxA16 antibody by gender and age groups have been summarized by using fixed- and random- effect models. All analyses have been conducted in STATA version 12.0 software.
A total of 14 publications with 9 in English and 5 in Chinese containing 9562 samples were finally included in the meta-analysis. The seroprevalence of CoxA16 antibody reported in different studies range from 24.85 to 76.92 %. Meta-analysis has revealed that the seroprevalence of CoxA16 antibody was 56.3 % (95 %CI: 47.7 %64.9 %) in the overall population and 55.1 % (95 %CI: 44.1 %66.1 %) in the Chinese population. Subgroup analysis by gender has revealed that the seroprevalence of CoxA16 antibody was 56.1 % (95 %CI: 45.2 %67.1 %) in males and 60.0 % (95 %CI: 50.0 %69.9 %) in females. Subgroup analysis by age groups has revealed that the seroprevalence of CoxA16 antibody was 49.1 % (95 %CI: 36.2 %62.0 %) in the 0 ~ 5 age group and 63.9 % (95 %CI: 53.1 %74.7 %) in the over 5 age group. Begg's funnel plots have suggested that there were no publication bias in all groups. Sensitive analysis has suggested that the result of the meta-analysis was stable.
The seroprevalence of CoxA16 antibody was closely related to age. Children under 5 years old were the main susceptible groups for CoxA16 and also the key groups for the prevention and control of HFMD.
柯萨奇病毒A16型（CoxA16）是引起手足口病（HFMD）的主要病原体，通常与肠道病毒71型（EV71）交替流行或共同流行。本研究的目的是通过系统评价和荟萃分析估计不同年龄组人群中CoxA16抗体的血清流行率。
从数据库建立之日至2021年1月，系统检索了关于人群中CoxA16抗体血清流行率的文献。采用固定效应模型和随机效应模型汇总了按性别和年龄组划分的CoxA16抗体血清流行率估计值。所有分析均在STATA 12.0软件中进行。
最终纳入荟萃分析的共有14篇文献，其中英文9篇，中文5篇，包含9562个样本。不同研究报告的CoxA16抗体血清流行率在24.85%至76.92%之间。荟萃分析显示，总体人群中CoxA16抗体的血清流行率为56.3%（95%CI：47.7%64.9%），中国人群中为55.1%（95%CI：44.1%66.1%）。按性别进行的亚组分析显示，男性中CoxA16抗体的血清流行率为56.1%（95%CI：45.2%67.1%），女性中为60.0%（95%CI：50.0%69.9%）。按年龄组进行的亚组分析显示，0至5岁年龄组中CoxA16抗体的血清流行率为49.1%（95%CI：36.2%62.0%），5岁以上年龄组中为63.9%（95%CI：53.1%74.7%）。Begg漏斗图表明所有组均无发表偏倚。敏感性分析表明荟萃分析结果稳定。
CoxA16抗体的血清流行率与年龄密切相关。5岁以下儿童是CoxA16的主要易感人群，也是手足口病防控的重点人群。
