Department of Molecular Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Laboratory of Phage Therapy, Institute of Biochemistry and Biophysics, Polish Academy of Science, Kładki 24, 80-822 Gdańsk, Poland.
Acta Biochim Pol. 2021 Sep 18;68(4):565-574. doi: 10.18388/abp.2020_5887.
Rapid development of antibiotic resistance of bacteria and fungi, as well as cancer drug resistance, has become a global medical problem. Therefore, alternative methods of treatment are considered. Studies of recent years have focused on finding new biologically active compounds that may be effective against drug-resistant cells. High biodiversity of hard-to-reach environments offers sources to search for novel molecules potentially applicable for medical purposes. In this review article, we summarize and discuss compounds produced by microorganisms from hot springs, glaciers, caves, underground lakes, marine ecosystems, and hydrothermal vents. Antibacterial, antiviral, antifungal, anticancer, anti-inflammatory, and antioxidant potential of these molecules are presented and discussed. We conclude that using compounds derived from microorganisms occurring in extreme environments might be considered in further studies on development of treatment procedures for diseases caused by drug-resistant cells.
细菌和真菌对抗生素的耐药性以及癌症耐药性的迅速发展，已成为全球性的医学问题。因此，人们考虑采用替代疗法。近年来的研究重点是寻找新的具有生物活性的化合物，这些化合物可能对耐药细胞有效。难以到达的环境具有高度的生物多样性，为寻找可能适用于医疗用途的新型分子提供了来源。在这篇综述文章中，我们总结和讨论了来自温泉、冰川、洞穴、地下湖、海洋生态系统和热液喷口的微生物产生的化合物。本文介绍并讨论了这些分子的抗菌、抗病毒、抗真菌、抗癌、抗炎和抗氧化潜力。我们的结论是，在研究针对耐药细胞引起的疾病的治疗方法时，可以考虑使用来源于极端环境中的微生物的化合物。
