Thylstrup A, Poulsen S
Scand J Dent Res. 1978 Jan;86(1):21-4. doi: 10.1111/j.1600-0722.1978.tb00603.x.
Following a single application of a chemically polymerized fissure sealant (Concise Enamel Bond System) 60% of the sealants were present after 2 years of examination. The effectiveness of the treatment was highly significant and the caries reduction, irrespective of the sealant status, was found to be about 50%. The caries reduction was 98% in sealed pairs where the material was fully retained.
在单次应用化学聚合裂隙封闭剂（简明釉质粘结系统）后，经过2年的检查，60%的封闭剂仍然存在。治疗效果非常显著，无论封闭剂的状态如何，龋齿减少率约为50%。在材料完全保留的封闭牙对中，龋齿减少率为98%。
