超重与胃肠道癌症风险
Excess Body Weight and Gastrointestinal Cancer Risk.
作者信息
Scherübl Hans
机构信息
Klinik für Innere Medizin II, Gastroenterologie, GI Onkologie, Diabetologie und Infektiologie, Vivantes Klinikum Am Urban, Berlin, Germany.
出版信息
Visc Med. 2021 Aug;37(4):261-266. doi: 10.1159/000515444. Epub 2021 Apr 13.
BACKGROUND
Excess body weight (EBW), defined as a body mass index (BMI) ≥25 kg/m, has become the second most important as well as a potentially modifiable risk factor for cancer in many industrialized countries. The more excess weight people have, the higher the risk of certain cancers. Over the past several decades, EBW has been increasing globally not only among adults, but also among children and adolescents.
SUMMARY
EBW is causally associated with colorectal, esophageal (adenocarcinoma), gastric (cardia), pancreatic, biliary and hepatocellular cancer. EBW when combined with tobacco smoking, risky alcohol use, or diabetes can act synergistically to cause gastrointestinal cancer. In recent years, more and more young adults (20-40 years old) were diagnosed with EBW-associated neoplasms. People with EBW should be encouraged to join cancer screening programs.
KEY MESSAGES
Keeping a healthy weight is a major public health concern and reduces the risk of cancer.
背景
超重（EBW）定义为体重指数（BMI）≥25kg/m²，在许多工业化国家已成为第二大重要且可能可改变的癌症风险因素。人们超重越多，患某些癌症的风险就越高。在过去几十年中，全球范围内超重现象不仅在成年人中增加，在儿童和青少年中也在增加。
总结
超重与结直肠癌、食管癌（腺癌）、胃癌（贲门癌）、胰腺癌、胆管癌和肝细胞癌存在因果关系。超重与吸烟、危险饮酒或糖尿病相结合时，可协同作用导致胃肠道癌症。近年来，越来越多的年轻人（20至40岁）被诊断出患有与超重相关的肿瘤。应鼓励超重者参加癌症筛查项目。
关键信息
保持健康体重是一项重大公共卫生问题，可降低患癌风险。
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