Fu Ya-Nan, Li Yongsan, Deng Bo, Yu Yingjie, Liu Fang, Wang Lei, Chen Guang, Tao Lei, Wei Yen, Wang Xing
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Bioact Mater. 2021 Jun 23;8:165-176. doi: 10.1016/j.bioactmat.2021.06.015. eCollection 2022 Feb.
A spatiotemporally dynamic therapy (SDT) is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment. Herein, dynamic chitosan-poly (ethylene glycol) (CP) Schiff-base linkages are employed to perform SDT by directly converting a liquid drug (KFX) into a gel formation. The obtained KFX-CP drug-gel with shape-adaptive property is used to treat a representative oral mucositis (OM) model in a spatiotemporally dynamic manner. The KFX-CP drug-gel creates an instructive microenvironment to regulate signaling biomolecules and endogenous cells behavior, thereby promoting OM healing by the rule of dynamically adjusting shape to fit the irregular OM regions first, and then provides space for tissue regeneration, over KFX potion control and the general hydrogel group of CP hydrogel and KFX-F127. Most interestingly, the regenerated tissue has ordered structure like healthy tissue. Therefore, the SDT provides a new approach for the design of next generation of wound dressing and tissue engineering materials.
一种时空动态疗法（SDT）被提出作为一种强大的治疗方式，它能使药物载体产生空间动态响应以适应伤口微环境。在此，通过直接将液态药物（KFX）转化为凝胶形态，利用动态壳聚糖-聚乙二醇（CP）席夫碱键来实现时空动态疗法。所获得的具有形状适应性的KFX-CP药物凝胶被用于以时空动态方式治疗典型的口腔黏膜炎（OM）模型。KFX-CP药物凝胶营造了一个具有指导作用的微环境来调节信号生物分子和内源性细胞行为，从而首先通过动态调整形状以适应不规则的OM区域的规则促进OM愈合，然后为组织再生提供空间，优于KFX溶液对照组以及CP水凝胶和KFX-F127的普通水凝胶组。最有趣的是，再生组织具有类似健康组织的有序结构。因此，时空动态疗法为下一代伤口敷料和组织工程材料的设计提供了一种新方法。
