Liu Wenguang, Wang Min, Cheng Wei, Niu Wen, Chen Mi, Luo Meng, Xie Chenxi, Leng Tongtong, Zhang Long, Lei Bo
Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710000, China.
Bioact Mater. 2020 Sep 23;6(3):721-728. doi: 10.1016/j.bioactmat.2020.09.008. eCollection 2021 Mar.
The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen (PCEI) and multifunctional PCEI-based F127-ε-polypeptide-alginic (FEA) dressing (FEA-PCEI) for accelerating wound healing and hair follicle neogenesis. PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization. The FEA-PCEI dressing showed the temperature-response gelation, injectability, robust antibacterial activity, light-damage-resistant, homeostasis ability, and good cytocompatibility. The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability, reduce the scar formation, and promote the hair follicle neogenesis. This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.
高效的皮肤伤口愈合并伴有增强的皮肤附属器再生仍然是一项挑战。细菌感染和过度/长时间的炎症会抑制伤口愈合过程并导致瘢痕形成。在此，我们报道了一种用于加速伤口愈合和毛囊新生的抗炎聚柠檬酸盐-聚乙烯亚胺-布洛芬（PCEI）以及基于多功能PCEI的F127-ε-多肽-海藻酸（FEA）敷料（FEA-PCEI）。PCEI通过刺激巨噬细胞向抗炎M2亚型极化表现出优异的抗炎功能。FEA-PCEI敷料具有温度响应凝胶化、可注射性、强大的抗菌活性、抗光损伤、内稳态能力以及良好的细胞相容性。优化剂量的FEA-PCEI敷料能够通过抗感染能力显著加速伤口愈合，减少瘢痕形成，并促进毛囊新生。本研究通过设计生物活性多功能生物材料调节免疫细胞表型提供了一种伤口修复策略。
