Gao Chengde, Zeng Zihao, Peng Shuping, Shuai Cijun
State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, China.
NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medical Science, Central South University, Changsha, 410078, Hunan, China.
Bioact Mater. 2021 Jun 30;8:177-195. doi: 10.1016/j.bioactmat.2021.06.025. eCollection 2022 Feb.
Magnetostrictive alloys have attracted increasing attention in biomedical applications because of the ability to generate reversible deformation in the presence of external magnetic fields. This review focuses on the advances in magnetostrictive alloys and their biomedical applications. The theories of magnetostriction are systematically summarized. The different types of magnetostrictive alloys and their preparation methods are also reviewed in detail. The magnetostrictive strains and phase compositions of typical magnetostrictive alloys, including iron based, rare-earth based and ferrite materials, are presented. Besides, a variety of approaches to preparing rods, blocks and films of magnetostriction materials, as well as the corresponding methods and setups for magnetostriction measurement, are summarized and discussed. Moreover, the interactions between magnetostrictive alloys and cells are analyzed and emphasis is placed on the transduction and transformation process of mechanochemical signals induced by magnetostriction. The latest applications of magnetostrictive alloys in remote microactuators, magnetic field sensors, wireless implantable devices and biodegradable implants are also reviewed. Furthermore, future research directions of magnetostrictive alloys are prospected with focus on their potential applications in remote cell actuation and bone repair.
磁致伸缩合金因其在外部磁场作用下产生可逆变形的能力，在生物医学应用中受到越来越多的关注。本文综述聚焦于磁致伸缩合金及其生物医学应用的进展。系统总结了磁致伸缩理论。还详细综述了不同类型的磁致伸缩合金及其制备方法。介绍了典型磁致伸缩合金（包括铁基、稀土基和铁氧体材料）的磁致伸缩应变和相组成。此外，总结并讨论了制备磁致伸缩材料棒、块和薄膜的各种方法，以及磁致伸缩测量的相应方法和装置。此外，分析了磁致伸缩合金与细胞之间的相互作用，并着重探讨了磁致伸缩诱导的机械化学信号的转导和转化过程。还综述了磁致伸缩合金在远程微致动器、磁场传感器、无线植入式设备和可生物降解植入物方面的最新应用。此外，展望了磁致伸缩合金未来的研究方向，重点关注其在远程细胞驱动和骨修复中的潜在应用。
