Shahid Sadoughi University of Medical Science, Yazd, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
BMC Res Notes. 2021 Sep 20;14(1):364. doi: 10.1186/s13104-021-05777-4.
The increased prevalence of metabolic dyslipidemia (MD) and its association with a variety of disorders raised a lot of attention to its management. Caveolin 1 (CAV1) the key protein in the caval structure of plasma membranes is many cell types that play an important role in its function. (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.
Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β = - 0.25 ± 132, P = 0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to the MIND diet may exhibit the lower dyslipidemia. This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.
代谢性血脂异常（MD）患病率的增加及其与多种疾病的关联引起了人们对其管理的高度关注。小窝蛋白 1（CAV1）是质膜小窝结构的关键蛋白，在许多细胞类型中发挥着重要作用。（CAV1）是与肥胖相关的已知基因。如今，一种被认为对整体健康有积极影响的新型饮食，即地中海饮食和地中海- DASH 干预神经退行性延迟饮食（MIND），已经被报道。因此，我们旨在研究 CAV1 多态性与 MIND 饮食对超重和肥胖患者 MD 的相互作用。
值得注意的是，在粗模型中，MIND 饮食与 CAV1 rs3807992 之间存在显著的血脂异常相互作用（β=−0.25±132，P=0.05）。其中，具有显性等位基因的受试者发生血脂异常的风险较低，而对 MIND 饮食依从性较高的风险等位基因携带者可能表现出较低的血脂异常。本研究将 CAV1 基因作为一种识别代谢性疾病高风险人群的可能遗传标志物。它还表明，通过与 CAV1 rs3807992 多态性可能存在的相互作用，使用 MIND 饮食可能有助于改善血脂异常。
