Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Cellular, Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
BMC Endocr Disord. 2021 Jul 1;21(1):138. doi: 10.1186/s12902-021-00800-y.
Caveolin-1 (CAV-1) is a cholesterol-dependent essential component located in caveolae. Several studies have been CAV-1 related to cardio-metabolic parameters in animal models, however, there are few studies in humans. Importantly, there is no study has investigated the interaction between CAV-1 rs3807992 gene and dietary patterns (DPs) on cardio-metabolic risk factors.
The current cross-sectional study was conducted on 404 overweight and obese women. Dietary intake was obtained from FFQ with 147 items. The CAV-1 genotype was measured by the PCR-RFLP method. The anthropometric measurements, serum lipid profile, and inflammatory markers were measured by standard protocols.
There was a significant interaction between CAV-1 rs3807992 and healthy DP on high-density cholesterol (HDL) (P-interaction = 0.03), TC/HDL (P-interaction = 0.03) and high sensitivity C-reactive protein (hs-CRP) (P-interaction = 0.04); in A-allele carriers, higher following a healthy DP was related to a higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy DP in relation to triglyceride (TG) (P-interaction = 0.001), aspartate aminotransferase (AST) (P-interaction = 0.01) and monocyte chemoattractant protein-1(MCP-1) (P-interaction = 0.01); A-allele carriers were more following the unhealthy DP had lower levels of TG, AST and MCP-1.
Our study revealed a significant gene-diet interaction between rs3807992 SNPs and DPs in relation to cardio-metabolic risk factors; A-allele carriers might be more sensitive to dietary composition compared to GG homozygotes. Following a healthy DP in A-allele-carriers may be improved their genetic association with cardio-metabolic risk factors.
窖蛋白-1（CAV-1）是一种位于小窝中的胆固醇依赖性必需成分。已有多项研究表明，动物模型中的 CAV-1 与心脏代谢参数有关，但在人类中研究较少。重要的是，目前还没有研究调查 CAV-1 rs3807992 基因与饮食模式（DPs）对心脏代谢危险因素的相互作用。
本横断面研究共纳入 404 名超重和肥胖女性。采用包含 147 个项目的 FFQ 来获取饮食摄入情况。采用 PCR-RFLP 法检测 CAV-1 基因型。采用标准方案测量人体测量学指标、血脂谱和炎症标志物。
CAV-1 rs3807992 与健康 DP 之间存在高密度胆固醇（HDL）（P 交互=0.03）、TC/HDL（P 交互=0.03）和高敏 C 反应蛋白（hs-CRP）（P 交互=0.04）的显著交互作用；在 A 等位基因携带者中，遵循健康 DP 与 HDL 水平升高以及 TC/HDL 和 hs-CRP 降低有关。此外，在与甘油三酯（TG）（P 交互=0.001）、天门冬氨酸氨基转移酶（AST）（P 交互=0.01）和单核细胞趋化蛋白-1（MCP-1）（P 交互=0.01）相关方面，也观察到 CAV-1 rs3807992 与不健康 DP 之间存在显著的交互作用；与遵循不健康 DP 的个体相比，A 等位基因携带者的 TG、AST 和 MCP-1 水平更低。
本研究揭示了 rs3807992 单核苷酸多态性与 DP 之间与心脏代谢危险因素相关的显著基因-饮食相互作用；与 GG 纯合子相比，A 等位基因携带者可能对饮食组成更敏感。在 A 等位基因携带者中遵循健康 DP 可能会改善他们与心脏代谢危险因素的遗传关联。
