Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan.
Koizumi Nest Animal Hospital, 3-24 Betto, Yahata Nishi, Kitakyushu, Fukuoka 806-0062, Japan.
J Vet Med Sci. 2021 Nov 16;83(11):1726-1729. doi: 10.1292/jvms.21-0302. Epub 2021 Sep 17.
Skin lesions possibly caused by Papillomavirus infections in two four-toed hedgehogs are described. In case 1, there was a papillary mass on the right hind limb. Histologically, the mass was consistent with a viral papilloma. In the other case, multifocal papillary masses with erosions and ulcers were found throughout the body, mainly on the extremities. Histology showed continuative lesions composed of acanthosis, Bowenoid in situ carcinoma, and squamous cell carcinoma, with abrupt transitions between the lesions. In both cases, keratinocytes in the granular layer infrequently had features of koilocytes and intranuclear inclusion bodies, and immunohistochemical staining was positive for anti-human papillomavirus antibody. To the best of the authors' knowledge, this is the first pathological documentation of possibly papillomavirus-associated skin lesions in four-toed hedgehogs.
描述了两只四趾刺猬可能由乳头瘤病毒感染引起的皮肤损伤。在案例 1 中，右后肢有一个乳头状肿块。组织学上，该肿块符合病毒性乳头瘤。在另一个病例中，全身多灶性乳头状肿块伴糜烂和溃疡，主要位于四肢。组织学显示连续性病变，由棘层肥厚、原位鲍文病和鳞状细胞癌组成，病变之间有突然的转变。在这两种情况下，颗粒层中的角质形成细胞偶尔具有空泡细胞和核内包涵体的特征，免疫组织化学染色对人乳头瘤病毒抗体呈阳性。据作者所知，这是首次在四趾刺猬中发现可能与乳头瘤病毒相关的皮肤损伤的病理记录。
