Breukink H J, Wagenaar G, Wensing T, Notermans S, Poulos P W
Tijdschr Diergeneeskd. 1978 Mar 15;103(6):303-11.
In 1977, outbreaks of disease associated with serious losses occurred on twenty cattle farms. This disease was due to the fact that the animals had been fed brewers' grains. The clinical picture was marked by anorexia, profuse salivation, regurgitation and dehydration. The course of the disease varied with the severity of the attack. Toxicological tests were negative. Cl. botulinum type B as well as toxin type B were found to be present in the brewers' grains fairly often. As a rule, Cl. botulinum was also detected in the rumen contents and faeces. The treatment of the animals is described; this resulted in recovery in a number of cases. When experimental animals were fed brewers' grains from farms on which outbreaks had occurred, this induced similar clinical pictures. The results of studies on the aetiology and pathogenesis are discussed. It is concluded that the clinical picture was an atypical form of botulism caused by Cl. botulinum type B. Possible causes of this abnormal clinical picture are discussed in greater detail.
1977年,20个养牛场发生了与严重损失相关的疾病暴发。这种疾病是由于动物食用了啤酒糟所致。临床症状表现为厌食、大量流涎、反刍和脱水。疾病的病程因发作的严重程度而异。毒理学检测呈阴性。在啤酒糟中相当频繁地发现了B型肉毒梭菌以及B型毒素。通常,在瘤胃内容物和粪便中也检测到了肉毒梭菌。描述了对动物的治疗方法;在一些病例中,动物得以康复。当给实验动物喂食来自发生疫情农场的啤酒糟时,引发了类似的临床症状。讨论了病因学和发病机制的研究结果。得出的结论是,临床症状是由B型肉毒梭菌引起的一种非典型肉毒中毒形式。更详细地讨论了这种异常临床症状的可能原因。